Unraveling the role of cigarette use in neural cannabis cue reactivity in heavy cannabis users

Lauren Kuhns, Emese Kroon, Francesca Filbey, Janna Cousijn

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Cue reactivity is an important biomarker of cannabis use disorder (CUD). Despite high rates of cigarette and cannabis co-use, its role in cannabis cue reactivity remains unclear. Using a visual functional magnetic resonance imaging cue reactivity paradigm, we investigated interactive effects of cannabis and cigarette use on cannabis cue relative to cigarette and neutral cue reactivity in a priori regions of interest-the amygdala, striatum, anterior cingulate cortex (ACC), ventral tegmental area (VTA), and orbitofrontal cortex-and a whole-brain analysis. In our sample of cannabis users and controls closely matched on cigarette use, significant interactions between cannabis and cigarette use status emerged in the amygdala, striatum, ACC, frontal pole, and inferior frontal gyrus. Cannabis-only users showed heightened cue reactivity in the amygdala compared with nonusing controls. Co-users did not show heightened cue reactivity compared with cigarette smoking controls, although cue-induced VTA activity was positively correlated with grams per week of cannabis. Cigarette smoking controls showed unexpectedly heightened cue reactivity compared to co-users and nonsmoking controls. These findings and the high prevalence of cannabis and cigarette co-use underscore the importance of considering cigarette smoking status when investigating the role of cue reactivity in heavy cannabis use.

Original languageEnglish
Article numbere12941
Pages (from-to)e12941
JournalAddiction Biology
Volume26
Issue number3
DOIs
Publication statusPublished - 5 Aug 2020
Externally publishedYes

Bibliographical note

Funding Information:
The authors would like to thank Sabrina Okx, Fabio Melis, Anne Kramer, and Scarlett Slagter for their help with data collection. This research was supported by grant 1R01 DA042490‐01A1 awarded to J.C. and F.F. from the National Institute on Drug Abuse/National Institutes of Health. Open access funding enabled and organized by Projekt DEAL.

Publisher Copyright:
© 2020 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction

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