Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease

Arfan Ikram, Marieke Oijen, Frank jan de Jong, Jan Kors, Peter Koudstaal, Bert Hofman, JCM Witteman, Monique Breteler

Research output: Contribution to journalArticleAcademicpeer-review

89 Citations (Scopus)


Background and Purpose-Men, but not women, with unrecognized myocardial infarction (MI) have an increased risk of cardiac events and stroke compared with those without MI or with recognized MI. We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies. Methods-In the Rotterdam Study, 6347 participants were classified at baseline (1990 to 1993) into those with recognized MI (subdivided into Q-wave and non-Q-wave MI), with unrecognized MI, and without MI based on electrocardiography and interview and were followed for incident dementia (n = 613) until January 1, 2005. In the Rotterdam Scan Study, 436 nondemented persons were similarly classified based on electrocardiography and interview and underwent brain MRI for the assessment of white matter lesions and brain infarction. Results-In men, unrecognized MI was associated with an increased risk of dementia (compared with men without MI hazard ratio, 2.14; 95% CI, 1.37 to 3.35) and with more white matter lesions and more often brain infarction on MRI. In women, no associations were found with unrecognized MI. Recognized MI was not associated with the risk of dementia in either sex. Men, but not women, with recognized MI had more often any brain infarction or asymptomatic brain infarction, especially if they had Q-wave MI. No consistent associations were found between recognized Q-wave or non-Q-wave MI and severity of white matter lesions. Additional adjustment for cardiovascular risk factors did not change the results. Conclusions-Men with unrecognized MI have an increased risk of dementia and more cerebral small vessel disease.
Original languageUndefined/Unknown
Pages (from-to)1421-1426
Number of pages6
Issue number5
Publication statusPublished - 2008

Research programs

  • EMC NIHES-01-64-01
  • EMC NIHES-03-77-02

Cite this