Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

Nikos Stratakis*, Eleni Papadopoulou, Anh N. Nguyen, Yinqi Zhao, Katerina Margetaki, Chung Ho E. Lau, Muireann Coen, Lea Maitre, Silvia Fernández-Barrés, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Barbara Heude, Rosemary R.C. McEachan, Helle Margrete Meltzer, Christopher MillettFernanda Rauber, Oliver Robinson, Theano Roumeliotaki, Eva Borras, Eduard Sabidó, Jose Urquiza, Marina Vafeiadi, Paolo Vineis, Trudy Voortman, John Wright, David V. Conti, Martine Vrijheid, Hector C. Keun, Leda Chatzi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
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Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used1H NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-methylnicotinic acid, urea, and sucrose) that was predictive of Mediterranean diet adherence (KIDMED) and ultra-processed food consumption and also had higher capacity in discriminating children’s diet quality than that of established sociodemographic determinants. Further, we showed that the identified metabolite panel also reflected the associations of these diet quality indicators with C-peptide, a stable and accurate marker of insulin resistance and future risk of metabolic disease. This methodology enables objective assessment of dietary patterns in European child populations, complementary to tradi-tional questionary methods, and can be used in future studies to evaluate diet quality. Moreover, this knowledge can provide mechanistic evidence of common biological pathways that characterize healthy and unhealthy dietary patterns, and diet-related molecular alterations that could associate to metabolic disease.

Original languageEnglish
Article numbere71332
Publication statusPublished - 25 Jan 2022

Bibliographical note

Publisher Copyright: © Stratakis et al.


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