Federated networks of observational health databases have the potential to be a rich resource to inform clinical practice and regulatory decision making. However, the lack of standard data quality processes makes it difficult to know if these data are research ready. The EHDEN COVID-19 Rapid Collaboration Call presented the opportunity to assess how the newly developed open-source tool Data Quality Dashboard (DQD) informs the quality of data in a federated network. Fifteen Data Partners (DPs) from 10 different countries worked with the EHDEN taskforce to map their data to the OMOP CDM. Throughout the process at least two DQD results were collected and compared for each DP. All DPs showed an improvement in their data quality between the first and last run of the DQD. The DQD excelled at helping DPs identify and fix conformance issues but showed less of an impact on completeness and plausibility checks. This is the first study to apply the DQD on multiple, disparate databases across a network. While study-specific checks should still be run, we recommend that all data holders converting their data to the OMOP CDM use the DQD as it ensures conformance to the model specifications and that a database meets a baseline level of completeness and plausibility for use in research.
Bibliographical noteFunding Information:
Funding: This research was funded by the European Union’s Horizon 2020 research and innovation programme and EFPIA, grant number 806968. The APC was funded by Janssen Research & Development, LLC.
This research was funded by the European Union?s Horizon 2020 research and innovation programme and EFPIA, grant number 806968. The APC was funded by Janssen Research & Development, LLC.The authors want to thank the data partners who participated in this research and the Innovative Medicines Initiative.
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