Vaccination of Macaques with adjuvanted formalin-inactivated influenza a virus (H5N1) vaccines: Protection against H5N1 challenge without disease enhancement

C Ruat, C Caillet, A Bidaut, J Simon, Ab Osterhaus

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Abstract

We investigated the ability of adjuvanted, inactivated split-virion influenza A virus (H5N1) vaccines to protect against infection and demonstrated that the disease exacerbation phenomenon seen with adjuvanted formaldehyde-inactivated respiratory syncytial virus and measles virus investigational vaccines did not occur with these H5N1 vaccines. Macaques were vaccinated twice with or without an aluminum hydroxide or oil-in-water emulsion adjuvanted vaccine. Three months later, animals were challenged with homologous wild-type H5N1. No signs of vaccine-induced disease exacerbation were seen. With either adjuvant, vaccination induced functional and cross-reactive antibodies and protected the lungs and upper respiratory tract. Without an adjuvant, the vaccine provided partial protection. Best results were obtained with the emulsion adjuvant.
Original languageUndefined/Unknown
Pages (from-to)2565-2569
Number of pages5
JournalJournal of Virology
Volume82
Issue number5
DOIs
Publication statusPublished - 2008

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