Vaccine design and delivery approaches for COVID-19

Kiana Shahzamani, Fatemeh Mahmoudian, Shahrzad Ahangarzadeh, Mohammad Mehdi Ranjbar, Leila Beikmohammadi, Samira Bahrami, Elmira Mohammadi, Sahar Esfandyari, Abbas Alibakhshi*, Shaghayegh Haghjooy Javanmard*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

10 Citations (Scopus)


COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scientific knowledge shows that designing and producing an effective vaccine is the best possible way to diminish the disease burden and dissemination or even eradicate the disease. Due to the urgent need, many vaccines are now available earlier than scheduled. New technologies have also helped to produce much more effective vaccines, although the potential side effects must be taken into account. Thus, in this review, the types of vaccines and vaccine designs made against COVID-19, the vaccination programs, as well as the delivery methods and molecules that have been used to deliver some vaccines that need a carrier will be described.

Original languageEnglish
Article number108086
JournalInternational Immunopharmacology
Early online date23 Aug 2021
Publication statusPublished - Nov 2021

Bibliographical note

Funding Information:
The project was supported by Isfahan University of Medical Sciences [grant number: 198231]. The authors would like to thank infectious Diseases and Tropical Medicine Research Center for kind supports.

Publisher Copyright:
© 2021 Elsevier B.V.


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