Vaccine-preventable diseases: Immune response in a large population of healthcare students

Paolo Emilio Santoro, Andrea Paladini, Ivan Borrelli, Carlotta Amantea*, Maria Francesca Rossi, Corinna Fortunato, Maria Rosaria Gualano, Antonio Marchetti, Chiara Cadeddu, Umberto Moscato

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: Students in medicine and other health professions are exposed to numerous occupational hazards, primarily biological hazards, during their academic careers at university. The aim of the present study was to investigate the seroprevalence characteristics of anti-HBsAg, anti-Measles, anti-Mumps, anti-Rubella and anti-Varicella IgG antibodies in healthcare students of a large teaching hospital in Rome. Methods: To accomplish the study's aims, antibody serology data were gathered from students of Medicine and Surgery, Dentistry, and Health Professions at the Catholic University of the Sacred Heart (Rome Campus) during their first Health Surveillance visit, that took place from 2013 to 2023. Results: Our study sample included 2523 students, 44.4 % were protected against Hepatitis B, 87.3 % against measles, 85.5 % against mumps, 94.6 % rubella and 95.2 % against varicella. Differences in antibody coverage between age groups were statistically significant (p < 0.001), except for mumps. It found a lower probability of having seronegative anti-HBVs with an older date since the presumed primary vaccination. Conclusion: In our sample, seropositivity rate against vaccine-preventable diseases, especially for Hepatitis B, was often inadequate to prevent possible biological risks connected with the activities carried out on the ward.

Original languageEnglish
Pages (from-to)930-936
Number of pages7
Issue number4
Early online date20 Jan 2024
Publication statusPublished - 6 Feb 2024

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