Validation of a single concentration methacholine inhalation provocation test (SCIPT) in children

Wanda Hagmolen Of Ten Have; N. J. Van Den Berg; J. Van Der Palen; P. J.E. Bindels; W. M.C. Van Aalderen

doi:10.1081/JAS-67934

Validation of a single concentration methacholine inhalation provocation test (SCIPT) in children

Wanda Hagmolen Of Ten Have^*, N. J. Van Den Berg, J. Van Der Palen, P. J.E. Bindels, W. M.C. Van Aalderen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Abstract

A new method to assess bronchial hyperresponsiveness (BHR) using a single concentration methacholine has already been validated in adults with asthma. Because the geometrical dimensions of the airways in children are different, the results from studies in adults cannot be extrapolated to children. In this study, we validated the single concentration methacholine inhalation provocation test (SCIPT) in children. Twenty-two children performed three methacholine inhalation challenge tests in random order. Two challenges were performed according to the SCIPT: doubling doses (0.03-1.8 mg; maximal cumulated dose 3.6 mg) were administered with an Aerosol Provocation System (Masterscope, Jaeger). The third challenge was performed according to a standard dosimeter method (SDM): doubling doses (0.002-1.8 mg; maximal cumulative dose 3.5 mg) were administered with a De Villbiss 646 nebulizer. The degree of BHR is expressed as a PD₂₀- A difference of < 1.5 dose step was assumed to be due to intraindividual variation. We found an intraclass correlation of 0.91 between both tests according to the SCIPT and of 0.80 between the SCIPT and SDM. We found, according to the method of Bland and Altman, good agreement when comparing these two challenge tests. The single concentration inhalation provocation test is reproducible and shows good agreement with a standard dosimeter method to test bronchial responsiveness in children.

Original language	English
Pages (from-to)	419-423
Number of pages	5
Journal	Journal of Asthma
Volume	42
Issue number	6
DOIs	https://doi.org/10.1081/JAS-67934
Publication status	Published - 2005
Externally published	Yes

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS We thank all patients and their parents for taking part in this study; Wim Hop, GlaxoSmithKline, for his statistical assistance, and Niesje E.Verhey and Saeeda J.A. Latif-Lone of the Lung Function Department of the Academic Medical Center, Amsterdam, for their critical remarks on the methods used. We also thank the ‘‘Stichting Astma Bestrijding’’ for financial support of the study. Wanda Hagmolen of ten Have is sponsored by GlaxoSmithKline.

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10.1081/JAS-67934

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title = "Validation of a single concentration methacholine inhalation provocation test (SCIPT) in children",

abstract = "A new method to assess bronchial hyperresponsiveness (BHR) using a single concentration methacholine has already been validated in adults with asthma. Because the geometrical dimensions of the airways in children are different, the results from studies in adults cannot be extrapolated to children. In this study, we validated the single concentration methacholine inhalation provocation test (SCIPT) in children. Twenty-two children performed three methacholine inhalation challenge tests in random order. Two challenges were performed according to the SCIPT: doubling doses (0.03-1.8 mg; maximal cumulated dose 3.6 mg) were administered with an Aerosol Provocation System (Masterscope, Jaeger). The third challenge was performed according to a standard dosimeter method (SDM): doubling doses (0.002-1.8 mg; maximal cumulative dose 3.5 mg) were administered with a De Villbiss 646 nebulizer. The degree of BHR is expressed as a PD20- A difference of < 1.5 dose step was assumed to be due to intraindividual variation. We found an intraclass correlation of 0.91 between both tests according to the SCIPT and of 0.80 between the SCIPT and SDM. We found, according to the method of Bland and Altman, good agreement when comparing these two challenge tests. The single concentration inhalation provocation test is reproducible and shows good agreement with a standard dosimeter method to test bronchial responsiveness in children.",

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ER -

Validation of a single concentration methacholine inhalation provocation test (SCIPT) in children

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