Validity of Simplified 3 '-Deoxy-3 '-[F-18]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer

M Lubberink; W Direcks; Jasper Emmering; H van Tinteren; OS Hoekstra; JJ van der Hoeven; CFM Molthoff; AA Lammertsma

doi:10.1007/s11307-012-0547-1

Validity of Simplified 3 '-Deoxy-3 '-[F-18]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer

M Lubberink, W Direcks, Jasper Emmering, H van Tinteren, OS Hoekstra, JJ van der Hoeven, CFM Molthoff, AA Lammertsma

Radiology & Nuclear Medicine

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: Positron emission tomography using 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [F-18]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [F-18]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [F-18]FLT, K (i) , determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [F-18]FLT.

Original language	Undefined/Unknown
Pages (from-to)	777-782
Number of pages	6
Journal	Molecular Imaging and Biology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/s11307-012-0547-1
Publication status	Published - 2012

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Cite this

Lubberink, M., Direcks, W., Emmering, J., van Tinteren, H., Hoekstra, OS., van der Hoeven, JJ., Molthoff, CFM., & Lammertsma, AA. (2012). Validity of Simplified 3 '-Deoxy-3 '-[F-18]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer. Molecular Imaging and Biology, 14(6), 777-782. https://doi.org/10.1007/s11307-012-0547-1

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abstract = "Purpose: Positron emission tomography using 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [F-18]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [F-18]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [F-18]FLT, K (i) , determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [F-18]FLT.",

author = "M Lubberink and W Direcks and Jasper Emmering and {van Tinteren}, H and OS Hoekstra and {van der Hoeven}, JJ and CFM Molthoff and AA Lammertsma",

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Lubberink, M, Direcks, W, Emmering, J, van Tinteren, H, Hoekstra, OS, van der Hoeven, JJ, Molthoff, CFM & Lammertsma, AA 2012, 'Validity of Simplified 3 '-Deoxy-3 '-[F-18]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer', Molecular Imaging and Biology, vol. 14, no. 6, pp. 777-782. https://doi.org/10.1007/s11307-012-0547-1

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T1 - Validity of Simplified 3 '-Deoxy-3 '-[F-18]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer

AU - Lubberink, M

AU - Direcks, W

AU - Emmering, Jasper

AU - van Tinteren, H

AU - Hoekstra, OS

AU - van der Hoeven, JJ

AU - Molthoff, CFM

AU - Lammertsma, AA

PY - 2012

Y1 - 2012

N2 - Purpose: Positron emission tomography using 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [F-18]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [F-18]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [F-18]FLT, K (i) , determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [F-18]FLT.

AB - Purpose: Positron emission tomography using 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [F-18]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [F-18]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [F-18]FLT, K (i) , determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [F-18]FLT.

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DO - 10.1007/s11307-012-0547-1

M3 - Article

VL - 14

SP - 777

EP - 782

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

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ER -