Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Magdi H. Yacoub*, Yuan Tsan Tseng, Jolanda Kluin, Annemijn Vis, Ulrich Stock, Hassiba Smail, Padmini Sarathchandra, Elena Aikawa, Hussam El-Nashar, Adrian H. Chester, Nairouz Shehata, Mohamed Nagy, Amr El-sawy, Wei Li, Gaetano Burriesci, Jacob Salmonsmith, Soha Romeih, Najma Latif

*Corresponding author for this work

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1 Citation (Scopus)
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Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.

Original languageEnglish
Article number1017
JournalCommunications Biology
Issue number1
Publication statusPublished - 7 Oct 2023

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