Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

EJ Benjamin, KM Rice, DE Arking, A Pfeufer, Charlotte Noord, AV Smith, RB Schnabel, JC Bis, E Boerwinkle, MF Sinner, Abbas Dehghan, SA Lubitz, RB D'Agostino, T Lumley, GB Ehret, Jan Heeringa, T Aspelund, C Newton-Cheh, MG Larson, KD MarcianteEZ Soliman, Fernando Rivadeneira, TJ Wang, G Eiriksdottir, D Levy, BM Psaty, M Li, AM Chamberlain, Bert Hofman, RS Vasan, TB Harris, JI Rotter, WHL Kao, SK Agarwal, Bruno Stricker, K Wang, LJ (Lenore) Launer, NL Smith, A Chakravarti, André Uitterlinden, PA Wolf, N Sotoodehnia, A Kottgen, Cornelia Duijn, T Meitinger, M Mueller, S Perz, G Steinbeck, HE Wichmann, KL Lunetta, SR Heckbert, V Gudnason, A Alonso, S Kaab, PT Ellinor, JCM Witteman

Research output: Contribution to journalArticleAcademicpeer-review

324 Citations (Scopus)


We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
Original languageUndefined/Unknown
Pages (from-to)879-881
Number of pages3
JournalNature Genetics
Issue number8
Publication statusPublished - 2009

Research programs

  • EMC MM-01-39-02
  • EMC NIHES-01-64-01
  • EMC NIHES-03-77-02

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