Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

EJ Benjamin; KM Rice; DE Arking; A Pfeufer; Charlotte Noord; AV Smith; RB Schnabel; JC Bis; E Boerwinkle; MF Sinner; Abbas Dehghan; SA Lubitz; RB D'Agostino; T Lumley; GB Ehret; Jan Heeringa; T Aspelund; C Newton-Cheh; MG Larson; KD Marciante; EZ Soliman; Fernando Rivadeneira; TJ Wang; G Eiriksdottir; D Levy; BM Psaty; M Li; AM Chamberlain; Bert Hofman; RS Vasan; TB Harris; JI Rotter; WHL Kao; SK Agarwal; Bruno Stricker; K Wang; LJ (Lenore) Launer; NL Smith; A Chakravarti; André Uitterlinden; PA Wolf; N Sotoodehnia; A Kottgen; Cornelia Duijn; T Meitinger; M Mueller; S Perz; G Steinbeck; HE Wichmann; KL Lunetta; SR Heckbert; V Gudnason; A Alonso; S Kaab; PT Ellinor; JCM Witteman

doi:10.1038/ng.416

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

EJ Benjamin
, KM Rice
, DE Arking
, A Pfeufer
, Charlotte Noord
, AV Smith
, RB Schnabel
, JC Bis
, E Boerwinkle
, MF Sinner
, Abbas Dehghan
, SA Lubitz
, RB D'Agostino
, T Lumley
, GB Ehret
, Jan Heeringa
, T Aspelund
, C Newton-Cheh
, MG Larson
, KD Marciante

EZ Soliman, Fernando Rivadeneira, TJ Wang, G Eiriksdottir, D Levy, BM Psaty, M Li, AM Chamberlain, Bert Hofman, RS Vasan, TB Harris, JI Rotter, WHL Kao, SK Agarwal, Bruno Stricker, K Wang, LJ (Lenore) Launer, NL Smith, A Chakravarti, André Uitterlinden, PA Wolf, N Sotoodehnia, A Kottgen, Cornelia Duijn, T Meitinger, M Mueller, S Perz, G Steinbeck, HE Wichmann, KL Lunetta, SR Heckbert, V Gudnason, A Alonso, S Kaab, PT Ellinor, JCM Witteman

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

344 Citations (Scopus)

Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

Original language	Undefined/Unknown
Pages (from-to)	879-881
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	8
DOIs	https://doi.org/10.1038/ng.416
Publication status	Published - 2009

Research programs

EMC MM-01-39-02
EMC NIHES-01-64-01
EMC NIHES-03-77-02

Access to Document

10.1038/ng.416

http://hdl.handle.net/1765/24581

Cite this

Benjamin, EJ., Rice, KM., Arking, DE., Pfeufer, A., Noord, C., Smith, AV., Schnabel, RB., Bis, JC., Boerwinkle, E., Sinner, MF., Dehghan, A., Lubitz, SA., D'Agostino, RB., Lumley, T., Ehret, GB., Heeringa, J., Aspelund, T., Newton-Cheh, C., Larson, MG., ... Witteman, JCM. (2009). Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nature Genetics, 41(8), 879-881. https://doi.org/10.1038/ng.416

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title = "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry",

abstract = "We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).",

author = "EJ Benjamin and KM Rice and DE Arking and A Pfeufer and Charlotte Noord and AV Smith and RB Schnabel and JC Bis and E Boerwinkle and MF Sinner and Abbas Dehghan and SA Lubitz and RB D'Agostino and T Lumley and GB Ehret and Jan Heeringa and T Aspelund and C Newton-Cheh and MG Larson and KD Marciante and EZ Soliman and Fernando Rivadeneira and TJ Wang and G Eiriksdottir and D Levy and BM Psaty and M Li and AM Chamberlain and Bert Hofman and RS Vasan and TB Harris and JI Rotter and WHL Kao and SK Agarwal and Bruno Stricker and K Wang and Launer, \{LJ (Lenore)\} and NL Smith and A Chakravarti and Andr{\'e} Uitterlinden and PA Wolf and N Sotoodehnia and A Kottgen and Cornelia Duijn and T Meitinger and M Mueller and S Perz and G Steinbeck and HE Wichmann and KL Lunetta and SR Heckbert and V Gudnason and A Alonso and S Kaab and PT Ellinor and JCM Witteman",

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Benjamin, EJ, Rice, KM, Arking, DE, Pfeufer, A, Noord, C, Smith, AV, Schnabel, RB, Bis, JC, Boerwinkle, E, Sinner, MF, Dehghan, A, Lubitz, SA, D'Agostino, RB, Lumley, T, Ehret, GB, Heeringa, J, Aspelund, T, Newton-Cheh, C, Larson, MG, Marciante, KD, Soliman, EZ, Rivadeneira, F, Wang, TJ, Eiriksdottir, G, Levy, D, Psaty, BM, Li, M, Chamberlain, AM, Hofman, B, Vasan, RS, Harris, TB, Rotter, JI, Kao, WHL, Agarwal, SK, Stricker, B, Wang, K, Launer, LJ, Smith, NL, Chakravarti, A, Uitterlinden, A, Wolf, PA, Sotoodehnia, N, Kottgen, A, Duijn, C, Meitinger, T, Mueller, M, Perz, S, Steinbeck, G, Wichmann, HE, Lunetta, KL, Heckbert, SR, Gudnason, V, Alonso, A, Kaab, S, Ellinor, PT & Witteman, JCM 2009, 'Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry', Nature Genetics, vol. 41, no. 8, pp. 879-881. https://doi.org/10.1038/ng.416

TY - JOUR

T1 - Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

AU - Benjamin, EJ

AU - Rice, KM

AU - Arking, DE

AU - Pfeufer, A

AU - Noord, Charlotte

AU - Smith, AV

AU - Schnabel, RB

AU - Bis, JC

AU - Boerwinkle, E

AU - Sinner, MF

AU - Dehghan, Abbas

AU - Lubitz, SA

AU - D'Agostino, RB

AU - Lumley, T

AU - Ehret, GB

AU - Heeringa, Jan

AU - Aspelund, T

AU - Newton-Cheh, C

AU - Larson, MG

AU - Marciante, KD

AU - Soliman, EZ

AU - Rivadeneira, Fernando

AU - Wang, TJ

AU - Eiriksdottir, G

AU - Levy, D

AU - Psaty, BM

AU - Li, M

AU - Chamberlain, AM

AU - Hofman, Bert

AU - Vasan, RS

AU - Harris, TB

AU - Rotter, JI

AU - Kao, WHL

AU - Agarwal, SK

AU - Stricker, Bruno

AU - Wang, K

AU - Launer, LJ (Lenore)

AU - Smith, NL

AU - Chakravarti, A

AU - Uitterlinden, André

AU - Wolf, PA

AU - Sotoodehnia, N

AU - Kottgen, A

AU - Duijn, Cornelia

AU - Meitinger, T

AU - Mueller, M

AU - Perz, S

AU - Steinbeck, G

AU - Wichmann, HE

AU - Lunetta, KL

AU - Heckbert, SR

AU - Gudnason, V

AU - Alonso, A

AU - Kaab, S

AU - Ellinor, PT

AU - Witteman, JCM

PY - 2009

Y1 - 2009

N2 - We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

AB - We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

U2 - 10.1038/ng.416

DO - 10.1038/ng.416

M3 - Article

SN - 1061-4036

VL - 41

SP - 879

EP - 881

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -