Vascular Compliance Changes of the Coronary Vessel Wall After Bioresorbable Vascular Scaffold Implantation in the Treated and Adjacent Segments

S Brugaletta, Bill Gkogkas, Hector Garcia Garcia, V Farooq, Chrysafios Girasis, JH Heo, Robert Jan van Geuns, B de Bruyne, D Dudek, J Koolen, P Smits, S Veldhof, R Rapoza, Yoshinobu Onuma, J Ormiston, PWJC (Patrick) Serruys

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Abstract

Background: Implantation of a metallic prosthesis creates local stiffness with a subsequent mismatch in the compliance of the vessel wall, disturbances in flow and heterogeneous distribution of wall shear stress. Polymeric bioresorbable ABSORB scaffolds have less stiffness than metallic platform stents. We sought to analyze the mismatch in vascular compliance after ABSORB implantation and its long-term resolution with bioresorption. Methods and Results: A total of 83 patients from the ABSORB trials underwent palpography investigations (30 and 53 patients from ABSORB Cohorts A and B, respectively) to measure the compliance of the scaffolded and adjacent segments at various time points (from pre-implantation up to 24 months). The mean of the maximum strain values was calculated per segment by utilizing the Rotterdam Classification (ROC) score and expressed as ROC/mm. Scaffold implantation lead to a significant decrease in vas Conclusions: The ABSORB scaffold decreases vascular compliance at the site of scaffold implantation. A compliance mismatch is evident immediately post-implantation and in contrast to metallic stents disappears in the mid-term, likely leading to a normalization of the rheological behavior of the scaffolded segment. (Circ J 2012; 76: 1616-1623)
Original languageUndefined/Unknown
Pages (from-to)1616-1623
Number of pages8
JournalCirculation Journal
Volume76
Issue number7
DOIs
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09

Cite this