Veno-arterial thrombosis and microcirculation imaging in a patient with COVID-19

Sakir Akin*, Daphne van Hooven, Can Ince, Tim Jansen

*Corresponding author for this work

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The Coronavirus pandemic has brought new challenges in intensive care medicine. Understanding of the pathophysiology of the vascular complications of SARS-CoV-2 infection could bring new resuscitation and therapeutic options. In this case report, we present a patient with COVID-19 pneumonia, who was admitted to our ICU and treated with high-flow nasal cannula, dexamethasone, remdesivir and high-dose prophylactic low molecular weight heparin. During ICU admission, substantial venous and arterial thrombosis developed. Meanwhile the microcirculation showed more than double amount of organ perfusion with very high total vessel density. We hypothesize that this might be a compensatory mechanism for the generalized prothrombic state in which the microcirculation increases the oxygen extraction capacity preventing multi-organ failure.

Original languageEnglish
Article number101428
JournalRespiratory Medicine Case Reports
Early online date11 May 2021
Publication statusPublished - 13 May 2021


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