Venous thromboembolism at time of diagnosis of ovarian cancer: Survival differs in symptomatic and asymptomatic cases

Owen Mortimer Heath*, Heleen J. Van Beekhuizen, Vivek Nama, Desiree Kolomainen, Marielle A.E. Nobbenhuis, Thomas E.J. Ind, Syed A. Sohaib, Fiona J. Lofts, Sue Heenan, Martin Gore, Susana Banerjee, Stan B. Kaye, Desmond P.J. Barton

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Objectives To determine the impact on survival of symptomatic and asymptomatic venous thromboembolism (VTE) at time of diagnosis of primary ovarian malignancy. Materials and methods The clinical records of 397 consecutive cases of primary ovarian malignancy were studied. Clinical, pathological and survival data were obtained. Results and conclusions Of 397 cases, 19 (4.8%) were found to have VTE at diagnosis, of which 63.2% (n = 12) were asymptomatic. VTE was significantly associated with reduced overall median survival (28 vs. 45 months, p = 0.004). Decreased survival was associated with symptomatic VTE compared to patients with asymptomatic VTE (21 vs. 36 months, p = 0.02) whose survival was similar to that of patients without VTE. Decreased survival remained significant in symptomatic patients after controlling for stage of disease at diagnosis, cytoreductive status and adjuvant chemotherapy use. Overall these data suggest for the first time that symptomatic but not asymptomatic VTE prior to primary treatment of ovarian cancer is an independent adverse prognostic factor.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalThrombosis Research
Volume137
DOIs
Publication statusPublished - 1 Jan 2016

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© 2015 Elsevier Ltd. All rights reserved.

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