Venous thromboembolism in childhood.

Heleen van Ommen, Marjolein Peters

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Venous thrombosis is an uncommon disorder in childhood with an incidence of about 1 in 100,000 children (ages 0 to 18 years). Multiple clinical underlying conditions as well as congenital prothrombotic disorders contribute to the development of pediatric venous thromboembolic disease. The majority of thrombi are catheter-related and therefore situated in the upper venous system. Diagnosis of thrombosis in either the upper or lower venous system is most frequently made by noninvasive radiographic techniques, especially ultrasonography. Children are treated according to recommendations based on small pediatric studies and guidelines adapted from adult patient protocols. The long-term complications, including mortality, recurrence, and the post-thrombotic syndrome, seem to be considerable. Because the incidence of pediatric venous thrombosis will probably rise due to the increased use of central venous catheters and the increased survival of children with chronic diseases associated with a prothrombotic state, prevention of this disease will become an important issue.
Original languageEnglish
Pages (from-to)391-404
JournalSeminars in Thrombosis and Hemostasis
Volume29
Issue number4
DOIs
Publication statusPublished - 2003
Externally publishedYes

Bibliographical note

© 2003 by Thieme Medical Publishers, Inc

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