Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis

Peter G.M. Mol; Patricia M.L.A. Van Den Bemt; Aileen B. Dequito; Jasperien E. van Doormaal; Rianne J. Zaal; Floor M. Haaijer-Ruskamp; Jos G.W. Kosterink

Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis

Translated title of the contribution: Preventable and non-preventable adverse drug events in hospitalized patients

Peter G.M. Mol^*
, Patricia M.L.A. Van Den Bemt
, Aileen B. Dequito
, Jasperien E. van Doormaal
, Rianne J. Zaal
, Floor M. Haaijer-Ruskamp
, Jos G.W. Kosterink

^*Corresponding author for this work

Pharmacy

University Medical Centre Groningen
Erasmus Universiteit Rotterdam / Het College ter Beoordeling van Geneesmiddelen (CBG)
Utrecht Institute of Pharmaceutical Sciences
Martini Ziekenhuis
University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To analyse the prevalence of preventable adverse drug events (pADEs) and non-preventable adverse drug reactions (ADRs) as well as the determinants of both pADEs and ADRs. METHODS: Adverse events experienced by patients admitted to two Dutch hospitals with functioning computerized physician order entry (CPOE) systems were prospectively identified through chart review. For both pADEs and non-preventable ADRs a causal relationship between adverse events and patients' drugs was established using the simplified Yale algorithm. RESULTS: pADEs and non-preventable ADRs were experienced by 349 (58%) patients, of whom 307 (88%) had non-preventable ADRs. Multi-morbidity (adjusted odds ratio [OR_adj] 1.90 and 1.28 respectively), length of stay (OR _adj 1.13 and 1.11), admission to the geriatric ward (OR_adj 7.78 and 3.82) and number of medication orders (OR_adj 1.25 and 1.13) were significantly associated with pADEs and ADRs. Admission to the gastroenterology/rheumatology ward (OR_adj 0.22 and 0.40) was inversely related to both pADEs and ADRs. Other determinants for ADRs only were female sex (OR_adj 1.77) and use of drugs affecting the nervous system (OR_adj 1.83). Age was a significant determinant for pADEs only (OR_adj 1.07). CONCLUSIONS: More than half of the patients admitted to the hospitals are harmed by drugs, of which most are non-serious, non-preventable ADRs. Determinants of both pADEs and ADRs overlap to a large extent. Our results imply the need for signalling early potential adverse events during the normal use of drugs in multimorbid patients or those in geriatric wards. Subsequent therapeutic interventions may improve their well-being more than focusing on errors in the medication process only.

Translated title of the contribution	Preventable and non-preventable adverse drug events in hospitalized patients
Original language	Dutch
Article number	a1331
Pages (from-to)	136-142
Number of pages	7
Journal	Pharmaceutisch Weekblad
Volume	7
Issue number	11
Publication status	Published - 15 Nov 2013

Bibliographical note

Dit artikel is een vertaling van: Dequito AB, Mol PG, van Doormaal JE, Zaal RJ, van den Bemt PM, Haaijer-Ruskamp FM, Kosterink JG. Preventable and non-preventable adverse drug events in hospitalized patients: a prospective chart review in the Netherlands. Drug Saf. 2011 nov 1;34(11):1089-100.
Deze vertaling verscheen eerder in Ned Tijdschr Geneeskd. 2013;157:A5051.

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@article{d3f58164cb7b4a1ea0c0b1cb95a51186,

title = "Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis",

abstract = "OBJECTIVE: To analyse the prevalence of preventable adverse drug events (pADEs) and non-preventable adverse drug reactions (ADRs) as well as the determinants of both pADEs and ADRs. METHODS: Adverse events experienced by patients admitted to two Dutch hospitals with functioning computerized physician order entry (CPOE) systems were prospectively identified through chart review. For both pADEs and non-preventable ADRs a causal relationship between adverse events and patients' drugs was established using the simplified Yale algorithm. RESULTS: pADEs and non-preventable ADRs were experienced by 349 (58\%) patients, of whom 307 (88\%) had non-preventable ADRs. Multi-morbidity (adjusted odds ratio [ORadj] 1.90 and 1.28 respectively), length of stay (OR adj 1.13 and 1.11), admission to the geriatric ward (ORadj 7.78 and 3.82) and number of medication orders (ORadj 1.25 and 1.13) were significantly associated with pADEs and ADRs. Admission to the gastroenterology/rheumatology ward (ORadj 0.22 and 0.40) was inversely related to both pADEs and ADRs. Other determinants for ADRs only were female sex (ORadj 1.77) and use of drugs affecting the nervous system (ORadj 1.83). Age was a significant determinant for pADEs only (ORadj 1.07). CONCLUSIONS: More than half of the patients admitted to the hospitals are harmed by drugs, of which most are non-serious, non-preventable ADRs. Determinants of both pADEs and ADRs overlap to a large extent. Our results imply the need for signalling early potential adverse events during the normal use of drugs in multimorbid patients or those in geriatric wards. Subsequent therapeutic interventions may improve their well-being more than focusing on errors in the medication process only.",

author = "Mol, \{Peter G.M.\} and \{Van Den Bemt\}, \{Patricia M.L.A.\} and Dequito, \{Aileen B.\} and \{van Doormaal\}, \{Jasperien E.\} and Zaal, \{Rianne J.\} and Haaijer-Ruskamp, \{Floor M.\} and Kosterink, \{Jos G.W.\}",

note = "Dit artikel is een vertaling van: Dequito AB, Mol PG, van Doormaal JE, Zaal RJ, van den Bemt PM, Haaijer-Ruskamp FM, Kosterink JG. Preventable and non-preventable adverse drug events in hospitalized patients: a prospective chart review in the Netherlands. Drug Saf. 2011 nov 1;34(11):1089-100. Deze vertaling verscheen eerder in Ned Tijdschr Geneeskd. 2013;157:A5051.",

year = "2013",

month = nov,

day = "15",

language = "Dutch",

volume = "7",

pages = "136--142",

journal = "Pharmaceutisch Weekblad",

issn = "0031-6911",

publisher = "Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP)",

number = "11",

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TY - JOUR

T1 - Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis

AU - Mol, Peter G.M.

AU - Van Den Bemt, Patricia M.L.A.

AU - Dequito, Aileen B.

AU - van Doormaal, Jasperien E.

AU - Zaal, Rianne J.

AU - Haaijer-Ruskamp, Floor M.

AU - Kosterink, Jos G.W.

N1 - Dit artikel is een vertaling van: Dequito AB, Mol PG, van Doormaal JE, Zaal RJ, van den Bemt PM, Haaijer-Ruskamp FM, Kosterink JG. Preventable and non-preventable adverse drug events in hospitalized patients: a prospective chart review in the Netherlands. Drug Saf. 2011 nov 1;34(11):1089-100. Deze vertaling verscheen eerder in Ned Tijdschr Geneeskd. 2013;157:A5051.

PY - 2013/11/15

Y1 - 2013/11/15

N2 - OBJECTIVE: To analyse the prevalence of preventable adverse drug events (pADEs) and non-preventable adverse drug reactions (ADRs) as well as the determinants of both pADEs and ADRs. METHODS: Adverse events experienced by patients admitted to two Dutch hospitals with functioning computerized physician order entry (CPOE) systems were prospectively identified through chart review. For both pADEs and non-preventable ADRs a causal relationship between adverse events and patients' drugs was established using the simplified Yale algorithm. RESULTS: pADEs and non-preventable ADRs were experienced by 349 (58%) patients, of whom 307 (88%) had non-preventable ADRs. Multi-morbidity (adjusted odds ratio [ORadj] 1.90 and 1.28 respectively), length of stay (OR adj 1.13 and 1.11), admission to the geriatric ward (ORadj 7.78 and 3.82) and number of medication orders (ORadj 1.25 and 1.13) were significantly associated with pADEs and ADRs. Admission to the gastroenterology/rheumatology ward (ORadj 0.22 and 0.40) was inversely related to both pADEs and ADRs. Other determinants for ADRs only were female sex (ORadj 1.77) and use of drugs affecting the nervous system (ORadj 1.83). Age was a significant determinant for pADEs only (ORadj 1.07). CONCLUSIONS: More than half of the patients admitted to the hospitals are harmed by drugs, of which most are non-serious, non-preventable ADRs. Determinants of both pADEs and ADRs overlap to a large extent. Our results imply the need for signalling early potential adverse events during the normal use of drugs in multimorbid patients or those in geriatric wards. Subsequent therapeutic interventions may improve their well-being more than focusing on errors in the medication process only.

AB - OBJECTIVE: To analyse the prevalence of preventable adverse drug events (pADEs) and non-preventable adverse drug reactions (ADRs) as well as the determinants of both pADEs and ADRs. METHODS: Adverse events experienced by patients admitted to two Dutch hospitals with functioning computerized physician order entry (CPOE) systems were prospectively identified through chart review. For both pADEs and non-preventable ADRs a causal relationship between adverse events and patients' drugs was established using the simplified Yale algorithm. RESULTS: pADEs and non-preventable ADRs were experienced by 349 (58%) patients, of whom 307 (88%) had non-preventable ADRs. Multi-morbidity (adjusted odds ratio [ORadj] 1.90 and 1.28 respectively), length of stay (OR adj 1.13 and 1.11), admission to the geriatric ward (ORadj 7.78 and 3.82) and number of medication orders (ORadj 1.25 and 1.13) were significantly associated with pADEs and ADRs. Admission to the gastroenterology/rheumatology ward (ORadj 0.22 and 0.40) was inversely related to both pADEs and ADRs. Other determinants for ADRs only were female sex (ORadj 1.77) and use of drugs affecting the nervous system (ORadj 1.83). Age was a significant determinant for pADEs only (ORadj 1.07). CONCLUSIONS: More than half of the patients admitted to the hospitals are harmed by drugs, of which most are non-serious, non-preventable ADRs. Determinants of both pADEs and ADRs overlap to a large extent. Our results imply the need for signalling early potential adverse events during the normal use of drugs in multimorbid patients or those in geriatric wards. Subsequent therapeutic interventions may improve their well-being more than focusing on errors in the medication process only.

UR - https://www.scopus.com/pages/publications/84890113219

M3 - Article

AN - SCOPUS:84890113219

SN - 0031-6911

VL - 7

SP - 136

EP - 142

JO - Pharmaceutisch Weekblad

JF - Pharmaceutisch Weekblad

IS - 11

M1 - a1331

ER -

Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis

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Vermijdbare en niet-vermijdbare medicatiegerelateerde schade in het ziekenhuis

Preventable and Non-Preventable Adverse Drug Events in Hospitalized Patients A Prospective Chart Review in the Netherlands

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