Very long-term clinical outcomes after direct stenting in patient presenting with ST-segment elevation myocardial infarction

Paola Scarparo, Riccardo Improta, Jeroen Wilschut, Isabella Kardys, Wijnand K. Den Dekker, Joost Daemen, Felix Zijlstra, Nicolas M. Van Mieghem, Roberto Diletti*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
7 Downloads (Pure)

Abstract

Background/Purpose: Direct Stenting (DS) could be associated with reduced distal embolization and improved reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). However, the impact of DS on long-term outcomes remains unclear, therefore we evaluated the impact of DS on very long-term clinical outcome in STEMI.  

Methods/Materials: Between April 2002 and December 2004, patients presenting with STEMI undergoing percutaneous coronary intervention were investigated. The study population was divided into two groups: DS and conventional stenting (CS) and stratified according to initial TIMI flow. Major adverse cardiac events (MACE) were assessed at 10 years and all-cause mortality at 15 years. Cox proportional hazards models were used. When the proportional hazards assumption was not satisfied, landmark analysis at mid-term (2 years) was performed.  

Results: A total of 812 consecutive patients were evaluated, 6 patients were excluded due to inadequate angiographic images, 450 (55.8%) underwent DS and 356 (44.2%) CS. At 15 years follow-up, DS was associated with a reduction in all-cause mortality (DS 35.0% vs. CS 45.3%, aHR 0.74, 95% CI 0.58–0.93, p = 0.010). The landmark analysis at 2 years identifies reduced 2-year MACE in DS compared with CS (6.8% vs.14%, aHR 0.67, 95% CI 0.49–0.93, p = 0.015) and beyond 2 years no significant differences were found between the groups (27.4% vs. 29.3%, aHR 1.00, 95% CI 0.74–1.36, p = 0.999). In patients with baseline TIMI 0–1, DS was associated with lower 10-year MACE and 15-year mortality compared with CS (aHR0.71, 95%CI 0.55–0.92, p = 0.010 and aHR0.65, 95%CI 0.50–0.84, p = 0.001, respectively).  

Conclusions: DS was associated with reduced 15-year all-cause mortality and reduced mid-term MACE rate in patients with STEMI. Clinical events reduction associated with DS was particularly relevant in patients with initial TIMI flow 0–1.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalCardiovascular Revascularization Medicine
Volume41
DOIs
Publication statusAccepted/In press - 19 Jan 2022

Bibliographical note

Funding Information:
None.

Publisher Copyright:
© 2022

Fingerprint

Dive into the research topics of 'Very long-term clinical outcomes after direct stenting in patient presenting with ST-segment elevation myocardial infarction'. Together they form a unique fingerprint.

Cite this