Visolie bij langdurige parenterale voeding bij kinderen.: omega-3-vetzuren hebben gunstig effect op lever

Robbert A.M. Strijbosch; Thelma L. van den Hoonaard; Joanne F. Olieman; Johanna C. Escher; Ian P. Alwayn; Hanneke Meijers-IJsselstijn

Visolie bij langdurige parenterale voeding bij kinderen. omega-3-vetzuren hebben gunstig effect op lever

Translated title of the contribution: Fish oil in prolonged parenteral nutrition in children: omega-3-fatty acids have a beneficial effect on the liver

Robbert A.M. Strijbosch^*, Thelma L. van den Hoonaard, Joanne F. Olieman, Johanna C. Escher, Ian P. Alwayn, Hanneke Meijers-IJsselstijn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

Neonates with intestinal failure are dependent on total parenteral nutrition (TPN) and therefore at risk for developing parenteral nutrition associated liver disease (PNALD). In this clinical lesson we report the treatment of PNALD in 3 infants with short bowel syndrome. Conventional omega-6 fat emulsion was substituted by omega-3 fish oil as the sole source of fat in TPN. The described patients were diagnosed as having multiple intestinal atresias, necrotizing enterocolitis and midgut volvulus, respectively, and all patients suffered from short bowel syndrome and were TPN-dependent. When persistent or progressive cholestasis occurred, omega-6 fat emulsion was replaced by omega-3 fish oil. In all 3 cases complete reversal of cholestasis was seen within months after the fish oil-fat emulsion switch. No negative side-effects were reported. These first experiences with the use of fish oil in children in the Netherlands confirm earlier suggested beneficial effects of omega-3 fatty acids in the treatment of PNALD in children with short bowel syndrome.

Translated title of the contribution	Fish oil in prolonged parenteral nutrition in children: omega-3-fatty acids have a beneficial effect on the liver
Original language	Dutch
Article number	A2003
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	154
Issue number	39
Publication status	Published - 13 Sept 2009

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Strijbosch, R. A. M., van den Hoonaard, T. L., Olieman, J. F., Escher, J. C., Alwayn, I. P., & Meijers-IJsselstijn, H. (2009). Visolie bij langdurige parenterale voeding bij kinderen. omega-3-vetzuren hebben gunstig effect op lever. Nederlands Tijdschrift voor Geneeskunde, 154(39), Article A2003. https://www.ntvg.nl/artikelen/visolie-bij-langdurige-parenterale-voeding-bij-kinderen

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title = "Visolie bij langdurige parenterale voeding bij kinderen.: omega-3-vetzuren hebben gunstig effect op lever",

abstract = "Neonates with intestinal failure are dependent on total parenteral nutrition (TPN) and therefore at risk for developing parenteral nutrition associated liver disease (PNALD). In this clinical lesson we report the treatment of PNALD in 3 infants with short bowel syndrome. Conventional omega-6 fat emulsion was substituted by omega-3 fish oil as the sole source of fat in TPN. The described patients were diagnosed as having multiple intestinal atresias, necrotizing enterocolitis and midgut volvulus, respectively, and all patients suffered from short bowel syndrome and were TPN-dependent. When persistent or progressive cholestasis occurred, omega-6 fat emulsion was replaced by omega-3 fish oil. In all 3 cases complete reversal of cholestasis was seen within months after the fish oil-fat emulsion switch. No negative side-effects were reported. These first experiences with the use of fish oil in children in the Netherlands confirm earlier suggested beneficial effects of omega-3 fatty acids in the treatment of PNALD in children with short bowel syndrome.",

author = "Strijbosch, {Robbert A.M.} and {van den Hoonaard}, {Thelma L.} and Olieman, {Joanne F.} and Escher, {Johanna C.} and Alwayn, {Ian P.} and Hanneke Meijers-IJsselstijn",

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journal = "Nederlands Tijdschrift voor Geneeskunde",

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AU - Strijbosch, Robbert A.M.

AU - van den Hoonaard, Thelma L.

AU - Olieman, Joanne F.

AU - Escher, Johanna C.

AU - Alwayn, Ian P.

AU - Meijers-IJsselstijn, Hanneke

PY - 2009/9/13

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N2 - Neonates with intestinal failure are dependent on total parenteral nutrition (TPN) and therefore at risk for developing parenteral nutrition associated liver disease (PNALD). In this clinical lesson we report the treatment of PNALD in 3 infants with short bowel syndrome. Conventional omega-6 fat emulsion was substituted by omega-3 fish oil as the sole source of fat in TPN. The described patients were diagnosed as having multiple intestinal atresias, necrotizing enterocolitis and midgut volvulus, respectively, and all patients suffered from short bowel syndrome and were TPN-dependent. When persistent or progressive cholestasis occurred, omega-6 fat emulsion was replaced by omega-3 fish oil. In all 3 cases complete reversal of cholestasis was seen within months after the fish oil-fat emulsion switch. No negative side-effects were reported. These first experiences with the use of fish oil in children in the Netherlands confirm earlier suggested beneficial effects of omega-3 fatty acids in the treatment of PNALD in children with short bowel syndrome.

AB - Neonates with intestinal failure are dependent on total parenteral nutrition (TPN) and therefore at risk for developing parenteral nutrition associated liver disease (PNALD). In this clinical lesson we report the treatment of PNALD in 3 infants with short bowel syndrome. Conventional omega-6 fat emulsion was substituted by omega-3 fish oil as the sole source of fat in TPN. The described patients were diagnosed as having multiple intestinal atresias, necrotizing enterocolitis and midgut volvulus, respectively, and all patients suffered from short bowel syndrome and were TPN-dependent. When persistent or progressive cholestasis occurred, omega-6 fat emulsion was replaced by omega-3 fish oil. In all 3 cases complete reversal of cholestasis was seen within months after the fish oil-fat emulsion switch. No negative side-effects were reported. These first experiences with the use of fish oil in children in the Netherlands confirm earlier suggested beneficial effects of omega-3 fatty acids in the treatment of PNALD in children with short bowel syndrome.

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AN - SCOPUS:78149491291

SN - 0028-2162

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JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 39

M1 - A2003

ER -

Visolie bij langdurige parenterale voeding bij kinderen. omega-3-vetzuren hebben gunstig effect op lever

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