Vitamin D: A modulator of cell proliferation and differentiation

H. A.P. Pols; J. C. Birkenhäger; J. A. Foekens; J. P.T.M. van Leeuwen

doi:10.1016/0960-0760(90)90435-N

Vitamin D: A modulator of cell proliferation and differentiation

H. A.P. Pols^*
, J. C. Birkenhäger
, J. A. Foekens
, J. P.T.M. van Leeuwen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

105 Citations (Scopus)

Abstract

1,25-Dihydroxyvitamin D₃, [1,25(OH)₂D₃], the biologically most active metabolite of vitamin D₃, is involved in the regulation of calcium homeostasis and bone metabolism. Recently, receptors for 1,25(OH)₂D₃ have also been shown in cells and tissues not directly related to calcium homeostasis. Experimental data obtained with leukemic and cancer cell lines, both in vitro and in vivo, showed the effects of 1,25(OH)₂D₃ on cell differentiation and proliferation. However, high doses of the sterol have to be used to observe these effects. Additional studies are needed to establish whether 1,25(OH)₂D₃ or suitable analogues have a therapeutic potential in malignant diseases without unacceptable toxicity like the development of hypercalcemia.

Original language	English
Pages (from-to)	873-876
Number of pages	4
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/0960-0760(90)90435-N
Publication status	Published - 20 Dec 1990

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Cite this

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title = "Vitamin D: A modulator of cell proliferation and differentiation",

abstract = "1,25-Dihydroxyvitamin D3, [1,25(OH)2D3], the biologically most active metabolite of vitamin D3, is involved in the regulation of calcium homeostasis and bone metabolism. Recently, receptors for 1,25(OH)2D3 have also been shown in cells and tissues not directly related to calcium homeostasis. Experimental data obtained with leukemic and cancer cell lines, both in vitro and in vivo, showed the effects of 1,25(OH)2D3 on cell differentiation and proliferation. However, high doses of the sterol have to be used to observe these effects. Additional studies are needed to establish whether 1,25(OH)2D3 or suitable analogues have a therapeutic potential in malignant diseases without unacceptable toxicity like the development of hypercalcemia.",

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doi = "10.1016/0960-0760(90)90435-N",

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TY - JOUR

T1 - Vitamin D

T2 - A modulator of cell proliferation and differentiation

AU - Pols, H. A.P.

AU - Birkenhäger, J. C.

AU - Foekens, J. A.

AU - van Leeuwen, J. P.T.M.

PY - 1990/12/20

Y1 - 1990/12/20

N2 - 1,25-Dihydroxyvitamin D3, [1,25(OH)2D3], the biologically most active metabolite of vitamin D3, is involved in the regulation of calcium homeostasis and bone metabolism. Recently, receptors for 1,25(OH)2D3 have also been shown in cells and tissues not directly related to calcium homeostasis. Experimental data obtained with leukemic and cancer cell lines, both in vitro and in vivo, showed the effects of 1,25(OH)2D3 on cell differentiation and proliferation. However, high doses of the sterol have to be used to observe these effects. Additional studies are needed to establish whether 1,25(OH)2D3 or suitable analogues have a therapeutic potential in malignant diseases without unacceptable toxicity like the development of hypercalcemia.

AB - 1,25-Dihydroxyvitamin D3, [1,25(OH)2D3], the biologically most active metabolite of vitamin D3, is involved in the regulation of calcium homeostasis and bone metabolism. Recently, receptors for 1,25(OH)2D3 have also been shown in cells and tissues not directly related to calcium homeostasis. Experimental data obtained with leukemic and cancer cell lines, both in vitro and in vivo, showed the effects of 1,25(OH)2D3 on cell differentiation and proliferation. However, high doses of the sterol have to be used to observe these effects. Additional studies are needed to establish whether 1,25(OH)2D3 or suitable analogues have a therapeutic potential in malignant diseases without unacceptable toxicity like the development of hypercalcemia.

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U2 - 10.1016/0960-0760(90)90435-N

DO - 10.1016/0960-0760(90)90435-N

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AN - SCOPUS:0025637268

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JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

IS - 6

ER -

Vitamin D: A modulator of cell proliferation and differentiation

Abstract

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