Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study

Y H M Krul-Poel; P P Koenders; R P Steegers-Theunissen; E Ten Boekel; M M Ter Wee; Y Louwers; P Lips; J S E Laven; S Simsek

doi:10.1371/journal.pone.0204748

Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study

Y H M Krul-Poel^*, P P Koenders, R P Steegers-Theunissen, E Ten Boekel, M M Ter Wee, Y Louwers, P Lips, J S E Laven, S Simsek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.

METHODS: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.

RESULTS: Serum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.

CONCLUSIONS: This study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.

Original language	English
Article number	e0204748
Number of pages	13
Journal	PLoS One (online)
Volume	13
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0204748
Publication status	Published - 4 Dec 2018

Bibliographical note

Funding: The HAVEN study was financially
supported by Corporate Development International
(grant 2005) and the Netherlands Heart Foundation
(grant 2002.B027). Although Prof. J.S.E. Laven
received funding from commercial sources:
Corporate Development International, Ferring,
Merck Serono, Merck Sharpe and Dome, Organon Shering Plough and Serono, this does not have any influence on the publication of this manuscript.

Research programs

EMC MM-01-52-07
EMC MM-03-54-04-A

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Cite this

@article{7117adfc46324df7bd7f2dacc18c9ca0,

title = "Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study",

abstract = "OBJECTIVE: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.METHODS: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.RESULTS: Serum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.CONCLUSIONS: This study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.",

author = "Krul-Poel, {Y H M} and Koenders, {P P} and Steegers-Theunissen, {R P} and {Ten Boekel}, E and Wee, {M M Ter} and Y Louwers and P Lips and Laven, {J S E} and S Simsek",

note = "Funding: The HAVEN study was financially supported by Corporate Development International (grant 2005) and the Netherlands Heart Foundation (grant 2002.B027). Although Prof. J.S.E. Laven received funding from commercial sources: Corporate Development International, Ferring, Merck Serono, Merck Sharpe and Dome, Organon Shering Plough and Serono, this does not have any influence on the publication of this manuscript.",

year = "2018",

month = dec,

day = "4",

doi = "10.1371/journal.pone.0204748",

language = "English",

volume = "13",

journal = "PLoS One (online)",

issn = "1932-6203",

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TY - JOUR

T1 - Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS)

T2 - A cross-sectional study

AU - Krul-Poel, Y H M

AU - Koenders, P P

AU - Steegers-Theunissen, R P

AU - Ten Boekel, E

AU - Wee, M M Ter

AU - Louwers, Y

AU - Lips, P

AU - Laven, J S E

AU - Simsek, S

N1 - Funding: The HAVEN study was financially supported by Corporate Development International (grant 2005) and the Netherlands Heart Foundation (grant 2002.B027). Although Prof. J.S.E. Laven received funding from commercial sources: Corporate Development International, Ferring, Merck Serono, Merck Sharpe and Dome, Organon Shering Plough and Serono, this does not have any influence on the publication of this manuscript.

PY - 2018/12/4

Y1 - 2018/12/4

N2 - OBJECTIVE: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.METHODS: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.RESULTS: Serum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.CONCLUSIONS: This study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.

AB - OBJECTIVE: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.METHODS: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.RESULTS: Serum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.CONCLUSIONS: This study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.

U2 - 10.1371/journal.pone.0204748

DO - 10.1371/journal.pone.0204748

M3 - Article

C2 - 30513089

SN - 1932-6203

VL - 13

JO - PLoS One (online)

JF - PLoS One (online)

IS - 12

M1 - e0204748

ER -

Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study

Abstract

Bibliographical note

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