Abstract
OBJECTIVE: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.
METHODS: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.
RESULTS: Serum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.
CONCLUSIONS: This study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.
Original language | English |
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Article number | e0204748 |
Number of pages | 13 |
Journal | PLoS One (online) |
Volume | 13 |
Issue number | 12 |
DOIs | |
Publication status | Published - 4 Dec 2018 |
Bibliographical note
Funding: The HAVEN study was financiallysupported by Corporate Development International
(grant 2005) and the Netherlands Heart Foundation
(grant 2002.B027). Although Prof. J.S.E. Laven
received funding from commercial sources:
Corporate Development International, Ferring,
Merck Serono, Merck Sharpe and Dome, Organon Shering Plough and Serono, this does not have any influence on the publication of this manuscript.
Research programs
- EMC MM-01-52-07
- EMC MM-03-54-04-A