TY - JOUR
T1 - Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
AU - Smolders, Joost
AU - Thewissen, Mariëlle
AU - Theunissen, Ruud
AU - Peelen, Evelyn
AU - Knippenberg, Stephanie
AU - Menheere, Paul
AU - Cohen Tervaert, Jan Willem
AU - Hupperts, Raymond
AU - Damoiseaux, Jan
PY - 2011/6
Y1 - 2011/6
N2 - An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-γ+ CD4+ T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment.
AB - An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-γ+ CD4+ T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment.
UR - https://www.scopus.com/pages/publications/79957994942
U2 - 10.1016/j.jneuroim.2011.03.012
DO - 10.1016/j.jneuroim.2011.03.012
M3 - Article
C2 - 21507492
AN - SCOPUS:79957994942
SN - 0165-5728
VL - 235
SP - 91
EP - 97
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -