Vitamin D Supplementation for Benign Paroxysmal Positional Vertigo: A Systematic Review

Xinyuan Hong, Marina Christ-Franco, David Moher, Darren Tse, Daniel A. Lelli, David Schramm, Lisa Caulley, Georgios Kontorinis

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)


Objective: Benign paroxysmal positional vertigo (BPPV) is commonly attributed to displaced otoconia. These have been shown to
have biomineralization close to that of bone, and vitamin D deficiency has been associated with BPPV. We aim to systematically review the available literature on vitamin D supplementation and
BPPV intensity and recurrence in adults.
Databases Reviewed: PubMed, MEDLINE, EMBASE, Cochrane
Central Register of Controlled Trials (CENTRAL), Current Controlled Trials, and
Methods: We systematically reviewed the available literature from
1947 to April 2020. The study protocol was registered in the PROSPERO database (trial registration: CRD42020183195).
Results: A total of 179 abstracts were identified and screened by two
independent reviewers. Based on inclusion and exclusion criteria, six
studies were selected and subjected to a quality assessment. In one
randomized clinical trial (RCT), vitamin D supplementation was
found to reduce annual recurrence rate of vertigo in patient with
BPPVand subnormal serum vitamin D levels compared with placebo
(odds ratio, 0.69; 95% confidence interval, 0.54–0.90). Non-RCTs
demonstrated the possibility of a null effect in the random effects
model (odds ratio, 0.08; 95% confidence interval, 0.00–1.56). The
RCT considered as low risk of bias. All of the nonrandomized studies
were assessed as serious risk of bias.
Conclusions: The intervention studies identified consistently demonstrated a decrease in BPPV recurrence with supplementation of vitamin D in patients with subnormal vitamin D levels. Although there
is a paucity of high-quality studies, the present literature does highlight a role for optimization of vitamin D levels in patients with BPPV
Original languageEnglish
Pages (from-to)E704-E711
JournalOtology & Neurotology
Issue number7
Publication statusPublished - Aug 2022

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