What is the value of stress Tc-99m-tetrofosmin myocardial perfusion imaging for the assessment of very long-term outcome in obese patients?

RS Korbee, Henk-Jan Boiten, M Ottenhof, R. Valkema, Ron van Domburg, Arend Schinkel

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Objective. There are no data regarding the long-term prognostic value of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in obese patients. The aim of this study was to examine the value of stress Tc-99m-tetrofosmin MPI findings for the prediction of very long-term outcome in obese patients. Methods. The study population consisted of 261 patients with a body mass index >= 30 kg/m(2) who underwent exercise or pharmacological stress Tc-99m-tetrofosmin MPI for the assessment of known or suspected coronary artery disease. Endpoints during follow-up were all-cause mortality, cardiac death, nonfatal infarction, and coronary revascularization. Kaplan-Meier survival cures were constructed and univariate and multivariate analyses were performed to identify predictors of very long-term outcom Results. The mean age was 59 +/- 10 years, 42% of the patients was male, and the body mass index was on average 37 +/- 7 kg/m(2). MPI findings were normal in 109 patients (42%). Myocardial perfusion abnormalities were fixed in 62 patients (24%) and reversible in 90 patients (34%). During a median 12-year follow-up, 91 (35%) patients died, and 27 (10%) had a nonfatal myocardial infarction. Survival curves were compared using the log-rank test at subsequent follow-up durations. Obese patients with Conclusion. Stress Tc-99m-tetrofosmin MPI provides valuable prognostic information for the prediction of outcome in obese patients. Obese patients with a normal stress Tc-99m-tetrofosmin study have a significantly better prognosis as compared with those with an abnormal study, up to 6 years after the test is performed. (J Nucl Cardiol 2013;20:227-33.)
Original languageUndefined/Unknown
Pages (from-to)227-233
Number of pages7
JournalJournal of Nuclear Cardiology
Issue number2
Publication statusPublished - 2013

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