Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

Benjamin J. Amberg, Ryan J. Hodges, Karyn A. Rodgers, Kelly J. Crossley, Stuart B. Hooper, Philip L.J. Dekoninck*

*Corresponding author for this work

Research output: Contribution to journalReview articleProfessionalpeer-review

13 Citations (Scopus)
44 Downloads (Pure)


Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.

Original languageEnglish
Pages (from-to)493-503
Number of pages11
JournalFetal Diagnosis and Therapy
Issue number7
Publication statusPublished - 1 Sept 2021

Bibliographical note

Funding Information:
This research was supported by an Australian Government Research Training Program Scholarship awarded to Benjamin Amberg at Monash University with Award number 25129015.

Publisher Copyright:
© 2021 The Author(s) Published by S. Karger AG, Basel.


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