X-changing information on X inactivation

Stefan Barakat, IH (Iris) Jonkers, Kim Monkhorst, Joost Gribnau

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved
Original languageUndefined/Unknown
Pages (from-to)679-687
Number of pages9
JournalExperimental Cell Research
Volume316
Issue number5
DOIs
Publication statusPublished - 2010

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