X-changing information on X inactivation

Stefan Barakat; IH (Iris) Jonkers; Kim Monkhorst; Joost Gribnau

doi:10.1016/j.yexcr.2010.01.015

X-changing information on X inactivation

Stefan Barakat, IH (Iris) Jonkers, Kim Monkhorst, Joost Gribnau

Developmental Biology

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

Abstract

In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved

Original language	Undefined/Unknown
Pages (from-to)	679-687
Number of pages	9
Journal	Experimental Cell Research
Volume	316
Issue number	5
DOIs	https://doi.org/10.1016/j.yexcr.2010.01.015
Publication status	Published - 2010

Research programs

EMC MGC-02-82-01

Access to Document

10.1016/j.yexcr.2010.01.015

http://hdl.handle.net/1765/19398

Cite this

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title = "X-changing information on X inactivation",

abstract = "In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved",

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T1 - X-changing information on X inactivation

AU - Barakat, Stefan

AU - Jonkers, IH (Iris)

AU - Monkhorst, Kim

AU - Gribnau, Joost

PY - 2010

Y1 - 2010

N2 - In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved

AB - In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved

U2 - 10.1016/j.yexcr.2010.01.015

DO - 10.1016/j.yexcr.2010.01.015

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