y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

YC Lu; FR Day; S Gustafsson; ML Buchkovich; JB Na; V Bataille; DL Cousminer; Z Dastani; AW Drong; T Esko; DM Evans; M Falchi; MF Feitosa; T Ferreira; AK Hedman; R Haring; PG Hysi; MM Iles; AE Justice; S Kanoni; V Lagou; R Li; X Li; A Locke; C Lu; R Magi; JRB Perry; TH Pers; QB Qi; M Sanna; EM Schmidt; WR Scott; D Shungin; A Teumer; AAE Vinkhuyzen; RW Walker; HJ Westra; MF Zhang; WH Zhang; JH Zhao; ZH Zhu; U Afzal; TS Ahluwalia; SJL Bakker; C Bellis; A Bonnefond; K Borodulin; AS Buchman; T Cederholm; AC Choh; HJ Choi; JE Curran; LCPGM (Lisette) de Groot; PL De Jager; RAM Dhonukshe-Rutten; Anke Enneman; E Eury; DS Evans; T Forsen; N Friedrich; F Fumeron; ME Garcia; S Gartner; BG Han; AS Havulinna; C Hayward; D Hernandez; H Hillege; T Ittermann; JW Kent; I Kolcic; T Laatikainen; J Lahti; IM Leach; CG Lee; JY Lee; T Liu; YF Liu; S Lobbens; M Loh; LP Lyytikainen; C Medina-Gomez; K Michaelsson; MA Nalls; CM Nielson; L Oozageer; L Pascoe; L Paternoster; O Polasek; S Ripatti; MA Sarzynski; CS Shin; NS Narancic; D Spira; P Srikanth; E Steinhagen-Thiessen; YJ Sung; KMA Swart; L Taittonen; T Tanaka; E Tikkanen; Nathalie van der Velde; NM Schoor; N (Niek) Verweij; AF Wright; L Yu; JM Zmuda; N Eklund; T Forrester; N Grarup; AU Jackson; K Kristiansson; T Kuulasmaa; J Kuusisto; P Lichtner; JA Luan; A Mahajan; S Mannisto; CD Palmer; JS Ried; RA Scott; A Stancakova; PJ Wagner; Ayse Demirkan; A Doring; V Gudnason; DP Kiel; B Kuhnel; M Mangino; B McKnight; C Menni; JR O'Connell; Ben Oostra; AR Shuldiner; KJ Song; L Vandenput; Cornelia Duijn; P Vollenweider; CC White; M Boehnke; Y Boettcher; RS Cooper; NG Forouhi; C Gieger; H Grallert; A Hingorani; T Jorgensen; P Jousilahti; M Kivimaki; M Kumari; M Laakso; C Langenberg; A Linneberg; A Luke; CA McKenzie; A Palotie; O Pedersen; A Peters; K Strauch; BO Tayo; NJ Wareham; DA Bennett; L Bertram; J Blangero; M Bluher; C Bouchard; H Campbell; NH Cho; SR Cummings; SA Czerwinski; I Demuth; R Eckardt; JG Eriksson; L Ferrucci; OH Franco Duran; P Froguel; RT Gansevoort; T Hansen; TB Harris; N Hastie; M Heliovaara; Bert Hofman; JM Jordan; A Jula; M Kahonen; E Kajantie; PB Knekt; S Koskinen; P Kovacs; T Lehtimaki; L Lind; YM Liu; ES Orwoll; C Osmond; M Perola; L Perusse; OT Raitakari; T Rankinen; DC Rao; TK Rice; Fernando Rivadeneira; I Rudan; V Salomaa; TIA Sorensen; M Stumvoll; A Tonjes; B Towne; GJ Tranah; A Tremblay; André Uitterlinden; P van der Harst; E Vartiainen; JS Viikari; V Vitart; MC Vohl; H Volzke; M Walker; H Wallaschofski; S Wild; JF Wilson; L Yengo; DT Bishop; IB Borecki; JC Chambers; LA Cupples; Abbas Dehghan; P Deloukas; G Fatemifar; C Fox; TS Furey; L Franke; JL Han; DJ Hunter; J Karjalainen; F Karpe; RC Kaplan; JS Kooner; MI McCarthy; JM Murabito; AP Morris; JAN Bishop; KE North; C Ohlsson; KK Ong; I Prokopenko; JB Richards; EE Schadt; TD Spector; E Widen; CJ Willer; Jiaqi Yang; E Ingelsson; KL Mohlke; JN Hirschhorn; JA Pospisilik; M.C. Zillikens; C Lindgren; TO Kilpelainen; RJF Loos

doi:10.1038/ncomms10495

y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

YC Lu, FR Day, S Gustafsson, ML Buchkovich, JB Na, V Bataille, DL Cousminer, Z Dastani, AW Drong, T Esko, DM Evans, M Falchi, MF Feitosa, T Ferreira, AK Hedman, R Haring, PG Hysi, MM Iles, AE Justice, S KanoniV Lagou, R Li, X Li, A Locke, C Lu, R Magi, JRB Perry, TH Pers, QB Qi, M Sanna, EM Schmidt, WR Scott, D Shungin, A Teumer, AAE Vinkhuyzen, RW Walker, HJ Westra, MF Zhang, WH Zhang, JH Zhao, ZH Zhu, U Afzal, TS Ahluwalia, SJL Bakker, C Bellis, A Bonnefond, K Borodulin, AS Buchman, T Cederholm, AC Choh, HJ Choi, JE Curran, LCPGM (Lisette) de Groot, PL De Jager, RAM Dhonukshe-Rutten, Anke Enneman, E Eury, DS Evans, T Forsen, N Friedrich, F Fumeron, ME Garcia, S Gartner, BG Han, AS Havulinna, C Hayward, D Hernandez, H Hillege, T Ittermann, JW Kent, I Kolcic, T Laatikainen, J Lahti, IM Leach, CG Lee, JY Lee, T Liu, YF Liu, S Lobbens, M Loh, LP Lyytikainen, C Medina-Gomez, K Michaelsson, MA Nalls, CM Nielson, L Oozageer, L Pascoe, L Paternoster, O Polasek, S Ripatti, MA Sarzynski, CS Shin, NS Narancic, D Spira, P Srikanth, E Steinhagen-Thiessen, YJ Sung, KMA Swart, L Taittonen, T Tanaka, E Tikkanen, Nathalie van der Velde, NM Schoor, N (Niek) Verweij, AF Wright, L Yu, JM Zmuda, N Eklund, T Forrester, N Grarup, AU Jackson, K Kristiansson, T Kuulasmaa, J Kuusisto, P Lichtner, JA Luan, A Mahajan, S Mannisto, CD Palmer, JS Ried, RA Scott, A Stancakova, PJ Wagner, Ayse Demirkan, A Doring, V Gudnason, DP Kiel, B Kuhnel, M Mangino, B McKnight, C Menni, JR O'Connell, Ben Oostra, AR Shuldiner, KJ Song, L Vandenput, Cornelia Duijn, P Vollenweider, CC White, M Boehnke, Y Boettcher, RS Cooper, NG Forouhi, C Gieger, H Grallert, A Hingorani, T Jorgensen, P Jousilahti, M Kivimaki, M Kumari, M Laakso, C Langenberg, A Linneberg, A Luke, CA McKenzie, A Palotie, O Pedersen, A Peters, K Strauch, BO Tayo, NJ Wareham, DA Bennett, L Bertram, J Blangero, M Bluher, C Bouchard, H Campbell, NH Cho, SR Cummings, SA Czerwinski, I Demuth, R Eckardt, JG Eriksson, L Ferrucci, OH Franco Duran, P Froguel, RT Gansevoort, T Hansen, TB Harris, N Hastie, M Heliovaara, Bert Hofman, JM Jordan, A Jula, M Kahonen, E Kajantie, PB Knekt, S Koskinen, P Kovacs, T Lehtimaki, L Lind, YM Liu, ES Orwoll, C Osmond, M Perola, L Perusse, OT Raitakari, T Rankinen, DC Rao, TK Rice, Fernando Rivadeneira, I Rudan, V Salomaa, TIA Sorensen, M Stumvoll, A Tonjes, B Towne, GJ Tranah, A Tremblay, André Uitterlinden, P van der Harst, E Vartiainen, JS Viikari, V Vitart, MC Vohl, H Volzke, M Walker, H Wallaschofski, S Wild, JF Wilson, L Yengo, DT Bishop, IB Borecki, JC Chambers, LA Cupples, Abbas Dehghan, P Deloukas, G Fatemifar, C Fox, TS Furey, L Franke, JL Han, DJ Hunter, J Karjalainen, F Karpe, RC Kaplan, JS Kooner, MI McCarthy, JM Murabito, AP Morris, JAN Bishop, KE North, C Ohlsson, KK Ong, I Prokopenko, JB Richards, EE Schadt, TD Spector, E Widen, CJ Willer, Jiaqi Yang, E Ingelsson, KL Mohlke, JN Hirschhorn, JA Pospisilik, M.C. Zillikens, C Lindgren, TO Kilpelainen, RJF Loos

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Original language	Undefined/Unknown
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms10495
Publication status	Published - 2016

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-01
EMC OR-01-39-08

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10.1038/ncomms10495

ncomms10495.pdfFinal published version, 1.95 MB

Cite this

Lu, YC., Day, FR., Gustafsson, S., Buchkovich, ML., Na, JB., Bataille, V., Cousminer, DL., Dastani, Z., Drong, AW., Esko, T., Evans, DM., Falchi, M., Feitosa, MF., Ferreira, T., Hedman, AK., Haring, R., Hysi, PG., Iles, MM., Justice, AE., ... Loos, RJF. (2016). y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7. https://doi.org/10.1038/ncomms10495

@article{af4e0306376d43238d37ca2b8c731352,

title = "y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk",

abstract = "To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.",

author = "YC Lu and FR Day and S Gustafsson and ML Buchkovich and JB Na and V Bataille and DL Cousminer and Z Dastani and AW Drong and T Esko and DM Evans and M Falchi and MF Feitosa and T Ferreira and AK Hedman and R Haring and PG Hysi and MM Iles and AE Justice and S Kanoni and V Lagou and R Li and X Li and A Locke and C Lu and R Magi and JRB Perry and TH Pers and QB Qi and M Sanna and EM Schmidt and WR Scott and D Shungin and A Teumer and AAE Vinkhuyzen and RW Walker and HJ Westra and MF Zhang and WH Zhang and JH Zhao and ZH Zhu and U Afzal and TS Ahluwalia and SJL Bakker and C Bellis and A Bonnefond and K Borodulin and AS Buchman and T Cederholm and AC Choh and HJ Choi and JE Curran and {de Groot}, {LCPGM (Lisette)} and {De Jager}, PL and RAM Dhonukshe-Rutten and Anke Enneman and E Eury and DS Evans and T Forsen and N Friedrich and F Fumeron and ME Garcia and S Gartner and BG Han and AS Havulinna and C Hayward and D Hernandez and H Hillege and T Ittermann and JW Kent and I Kolcic and T Laatikainen and J Lahti and IM Leach and CG Lee and JY Lee and T Liu and YF Liu and S Lobbens and M Loh and LP Lyytikainen and C Medina-Gomez and K Michaelsson and MA Nalls and CM Nielson and L Oozageer and L Pascoe and L Paternoster and O Polasek and S Ripatti and MA Sarzynski and CS Shin and NS Narancic and D Spira and P Srikanth and E Steinhagen-Thiessen and YJ Sung and KMA Swart and L Taittonen and T Tanaka and E Tikkanen and {van der Velde}, Nathalie and NM Schoor and Verweij, {N (Niek)} and AF Wright and L Yu and JM Zmuda and N Eklund and T Forrester and N Grarup and AU Jackson and K Kristiansson and T Kuulasmaa and J Kuusisto and P Lichtner and JA Luan and A Mahajan and S Mannisto and CD Palmer and JS Ried and RA Scott and A Stancakova and PJ Wagner and Ayse Demirkan and A Doring and V Gudnason and DP Kiel and B Kuhnel and M Mangino and B McKnight and C Menni and JR O'Connell and Ben Oostra and AR Shuldiner and KJ Song and L Vandenput and Cornelia Duijn and P Vollenweider and CC White and M Boehnke and Y Boettcher and RS Cooper and NG Forouhi and C Gieger and H Grallert and A Hingorani and T Jorgensen and P Jousilahti and M Kivimaki and M Kumari and M Laakso and C Langenberg and A Linneberg and A Luke and CA McKenzie and A Palotie and O Pedersen and A Peters and K Strauch and BO Tayo and NJ Wareham and DA Bennett and L Bertram and J Blangero and M Bluher and C Bouchard and H Campbell and NH Cho and SR Cummings and SA Czerwinski and I Demuth and R Eckardt and JG Eriksson and L Ferrucci and {Franco Duran}, OH and P Froguel and RT Gansevoort and T Hansen and TB Harris and N Hastie and M Heliovaara and Bert Hofman and JM Jordan and A Jula and M Kahonen and E Kajantie and PB Knekt and S Koskinen and P Kovacs and T Lehtimaki and L Lind and YM Liu and ES Orwoll and C Osmond and M Perola and L Perusse and OT Raitakari and T Rankinen and DC Rao and TK Rice and Fernando Rivadeneira and I Rudan and V Salomaa and TIA Sorensen and M Stumvoll and A Tonjes and B Towne and GJ Tranah and A Tremblay and Andr{\'e} Uitterlinden and {van der Harst}, P and E Vartiainen and JS Viikari and V Vitart and MC Vohl and H Volzke and M Walker and H Wallaschofski and S Wild and JF Wilson and L Yengo and DT Bishop and IB Borecki and JC Chambers and LA Cupples and Abbas Dehghan and P Deloukas and G Fatemifar and C Fox and TS Furey and L Franke and JL Han and DJ Hunter and J Karjalainen and F Karpe and RC Kaplan and JS Kooner and MI McCarthy and JM Murabito and AP Morris and JAN Bishop and KE North and C Ohlsson and KK Ong and I Prokopenko and JB Richards and EE Schadt and TD Spector and E Widen and CJ Willer and Jiaqi Yang and E Ingelsson and KL Mohlke and JN Hirschhorn and JA Pospisilik and M.C. Zillikens and C Lindgren and TO Kilpelainen and RJF Loos",

year = "2016",

doi = "10.1038/ncomms10495",

language = "Undefined/Unknown",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Lu, YC, Day, FR, Gustafsson, S, Buchkovich, ML, Na, JB, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, AK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Magi, R, Perry, JRB, Pers, TH, Qi, QB, Sanna, M, Schmidt, EM, Scott, WR, Shungin, D, Teumer, A, Vinkhuyzen, AAE, Walker, RW, Westra, HJ, Zhang, MF, Zhang, WH, Zhao, JH, Zhu, ZH, Afzal, U, Ahluwalia, TS, Bakker, SJL, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, AS, Cederholm, T, Choh, AC, Choi, HJ, Curran, JE, de Groot, LCPGM, De Jager, PL, Dhonukshe-Rutten, RAM, Enneman, A, Eury, E, Evans, DS, Forsen, T, Friedrich, N, Fumeron, F, Garcia, ME, Gartner, S, Han, BG, Havulinna, AS, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, JW, Kolcic, I, Laatikainen, T, Lahti, J, Leach, IM, Lee, CG, Lee, JY, Liu, T, Liu, YF, Lobbens, S, Loh, M, Lyytikainen, LP, Medina-Gomez, C, Michaelsson, K, Nalls, MA, Nielson, CM, Oozageer, L, Pascoe, L, Paternoster, L, Polasek, O, Ripatti, S, Sarzynski, MA, Shin, CS, Narancic, NS, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, YJ, Swart, KMA, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, Schoor, NM, Verweij, N, Wright, AF, Yu, L, Zmuda, JM, Eklund, N, Forrester, T, Grarup, N, Jackson, AU, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, JA, Mahajan, A, Mannisto, S, Palmer, CD, Ried, JS, Scott, RA, Stancakova, A, Wagner, PJ, Demirkan, A, Doring, A, Gudnason, V, Kiel, DP, Kuhnel, B, Mangino, M, McKnight, B, Menni, C, O'Connell, JR, Oostra, B, Shuldiner, AR, Song, KJ, Vandenput, L, Duijn, C, Vollenweider, P, White, CC, Boehnke, M, Boettcher, Y, Cooper, RS, Forouhi, NG, Gieger, C, Grallert, H, Hingorani, A, Jorgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, McKenzie, CA, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, BO, Wareham, NJ, Bennett, DA, Bertram, L, Blangero, J, Bluher, M, Bouchard, C, Campbell, H, Cho, NH, Cummings, SR, Czerwinski, SA, Demuth, I, Eckardt, R, Eriksson, JG, Ferrucci, L, Franco Duran, OH, Froguel, P, Gansevoort, RT, Hansen, T, Harris, TB, Hastie, N, Heliovaara, M, Hofman, B, Jordan, JM, Jula, A, Kahonen, M, Kajantie, E, Knekt, PB, Koskinen, S, Kovacs, P, Lehtimaki, T, Lind, L, Liu, YM, Orwoll, ES, Osmond, C, Perola, M, Perusse, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Rivadeneira, F, Rudan, I, Salomaa, V, Sorensen, TIA, Stumvoll, M, Tonjes, A, Towne, B, Tranah, GJ, Tremblay, A, Uitterlinden, A, van der Harst, P, Vartiainen, E, Viikari, JS, Vitart, V, Vohl, MC, Volzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, JF, Yengo, L, Bishop, DT, Borecki, IB, Chambers, JC, Cupples, LA, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, TS, Franke, L, Han, JL, Hunter, DJ, Karjalainen, J, Karpe, F, Kaplan, RC, Kooner, JS, McCarthy, MI, Murabito, JM, Morris, AP, Bishop, JAN, North, KE, Ohlsson, C, Ong, KK, Prokopenko, I, Richards, JB, Schadt, EE, Spector, TD, Widen, E, Willer, CJ, Yang, J, Ingelsson, E, Mohlke, KL, Hirschhorn, JN, Pospisilik, JA, Zillikens, MC, Lindgren, C, Kilpelainen, TO & Loos, RJF 2016, 'y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk', Nature Communications, vol. 7. https://doi.org/10.1038/ncomms10495

TY - JOUR

T1 - y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

AU - Lu, YC

AU - Day, FR

AU - Gustafsson, S

AU - Buchkovich, ML

AU - Na, JB

AU - Bataille, V

AU - Cousminer, DL

AU - Dastani, Z

AU - Drong, AW

AU - Esko, T

AU - Evans, DM

AU - Falchi, M

AU - Feitosa, MF

AU - Ferreira, T

AU - Hedman, AK

AU - Haring, R

AU - Hysi, PG

AU - Iles, MM

AU - Justice, AE

AU - Kanoni, S

AU - Lagou, V

AU - Li, R

AU - Li, X

AU - Locke, A

AU - Lu, C

AU - Magi, R

AU - Perry, JRB

AU - Pers, TH

AU - Qi, QB

AU - Sanna, M

AU - Schmidt, EM

AU - Scott, WR

AU - Shungin, D

AU - Teumer, A

AU - Vinkhuyzen, AAE

AU - Walker, RW

AU - Westra, HJ

AU - Zhang, MF

AU - Zhang, WH

AU - Zhao, JH

AU - Zhu, ZH

AU - Afzal, U

AU - Ahluwalia, TS

AU - Bakker, SJL

AU - Bellis, C

AU - Bonnefond, A

AU - Borodulin, K

AU - Buchman, AS

AU - Cederholm, T

AU - Choh, AC

AU - Choi, HJ

AU - Curran, JE

AU - de Groot, LCPGM (Lisette)

AU - De Jager, PL

AU - Dhonukshe-Rutten, RAM

AU - Enneman, Anke

AU - Eury, E

AU - Evans, DS

AU - Forsen, T

AU - Friedrich, N

AU - Fumeron, F

AU - Garcia, ME

AU - Gartner, S

AU - Han, BG

AU - Havulinna, AS

AU - Hayward, C

AU - Hernandez, D

AU - Hillege, H

AU - Ittermann, T

AU - Kent, JW

AU - Kolcic, I

AU - Laatikainen, T

AU - Lahti, J

AU - Leach, IM

AU - Lee, CG

AU - Lee, JY

AU - Liu, T

AU - Liu, YF

AU - Lobbens, S

AU - Loh, M

AU - Lyytikainen, LP

AU - Medina-Gomez, C

AU - Michaelsson, K

AU - Nalls, MA

AU - Nielson, CM

AU - Oozageer, L

AU - Pascoe, L

AU - Paternoster, L

AU - Polasek, O

AU - Ripatti, S

AU - Sarzynski, MA

AU - Shin, CS

AU - Narancic, NS

AU - Spira, D

AU - Srikanth, P

AU - Steinhagen-Thiessen, E

AU - Sung, YJ

AU - Swart, KMA

AU - Taittonen, L

AU - Tanaka, T

AU - Tikkanen, E

AU - van der Velde, Nathalie

AU - Schoor, NM

AU - Verweij, N (Niek)

AU - Wright, AF

AU - Yu, L

AU - Zmuda, JM

AU - Eklund, N

AU - Forrester, T

AU - Grarup, N

AU - Jackson, AU

AU - Kristiansson, K

AU - Kuulasmaa, T

AU - Kuusisto, J

AU - Lichtner, P

AU - Luan, JA

AU - Mahajan, A

AU - Mannisto, S

AU - Palmer, CD

AU - Ried, JS

AU - Scott, RA

AU - Stancakova, A

AU - Wagner, PJ

AU - Demirkan, Ayse

AU - Doring, A

AU - Gudnason, V

AU - Kiel, DP

AU - Kuhnel, B

AU - Mangino, M

AU - McKnight, B

AU - Menni, C

AU - O'Connell, JR

AU - Oostra, Ben

AU - Shuldiner, AR

AU - Song, KJ

AU - Vandenput, L

AU - Duijn, Cornelia

AU - Vollenweider, P

AU - White, CC

AU - Boehnke, M

AU - Boettcher, Y

AU - Cooper, RS

AU - Forouhi, NG

AU - Gieger, C

AU - Grallert, H

AU - Hingorani, A

AU - Jorgensen, T

AU - Jousilahti, P

AU - Kivimaki, M

AU - Kumari, M

AU - Laakso, M

AU - Langenberg, C

AU - Linneberg, A

AU - Luke, A

AU - McKenzie, CA

AU - Palotie, A

AU - Pedersen, O

AU - Peters, A

AU - Strauch, K

AU - Tayo, BO

AU - Wareham, NJ

AU - Bennett, DA

AU - Bertram, L

AU - Blangero, J

AU - Bluher, M

AU - Bouchard, C

AU - Campbell, H

AU - Cho, NH

AU - Cummings, SR

AU - Czerwinski, SA

AU - Demuth, I

AU - Eckardt, R

AU - Eriksson, JG

AU - Ferrucci, L

AU - Franco Duran, OH

AU - Froguel, P

AU - Gansevoort, RT

AU - Hansen, T

AU - Harris, TB

AU - Hastie, N

AU - Heliovaara, M

AU - Hofman, Bert

AU - Jordan, JM

AU - Jula, A

AU - Kahonen, M

AU - Kajantie, E

AU - Knekt, PB

AU - Koskinen, S

AU - Kovacs, P

AU - Lehtimaki, T

AU - Lind, L

AU - Liu, YM

AU - Orwoll, ES

AU - Osmond, C

AU - Perola, M

AU - Perusse, L

AU - Raitakari, OT

AU - Rankinen, T

AU - Rao, DC

AU - Rice, TK

AU - Rivadeneira, Fernando

AU - Rudan, I

AU - Salomaa, V

AU - Sorensen, TIA

AU - Stumvoll, M

AU - Tonjes, A

AU - Towne, B

AU - Tranah, GJ

AU - Tremblay, A

AU - Uitterlinden, André

AU - van der Harst, P

AU - Vartiainen, E

AU - Viikari, JS

AU - Vitart, V

AU - Vohl, MC

AU - Volzke, H

AU - Walker, M

AU - Wallaschofski, H

AU - Wild, S

AU - Wilson, JF

AU - Yengo, L

AU - Bishop, DT

AU - Borecki, IB

AU - Chambers, JC

AU - Cupples, LA

AU - Dehghan, Abbas

AU - Deloukas, P

AU - Fatemifar, G

AU - Fox, C

AU - Furey, TS

AU - Franke, L

AU - Han, JL

AU - Hunter, DJ

AU - Karjalainen, J

AU - Karpe, F

AU - Kaplan, RC

AU - Kooner, JS

AU - McCarthy, MI

AU - Murabito, JM

AU - Morris, AP

AU - Bishop, JAN

AU - North, KE

AU - Ohlsson, C

AU - Ong, KK

AU - Prokopenko, I

AU - Richards, JB

AU - Schadt, EE

AU - Spector, TD

AU - Widen, E

AU - Willer, CJ

AU - Yang, Jiaqi

AU - Ingelsson, E

AU - Mohlke, KL

AU - Hirschhorn, JN

AU - Pospisilik, JA

AU - Zillikens, M.C.

AU - Lindgren, C

AU - Kilpelainen, TO

AU - Loos, RJF

PY - 2016

Y1 - 2016

N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

U2 - 10.1038/ncomms10495

DO - 10.1038/ncomms10495

M3 - Article

C2 - 26833246

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

ER -