Abstract
| Original language | Undefined/Unknown |
|---|---|
| Journal | Nature Communications |
| Volume | 7 |
| DOIs | |
| Publication status | Published - 2016 |
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y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. / Lu, YC; Day, FR; Gustafsson, S; Buchkovich, ML; Na, JB; Bataille, V; Cousminer, DL; Dastani, Z; Drong, AW; Esko, T; Evans, DM; Falchi, M; Feitosa, MF; Ferreira, T; Hedman, AK; Haring, R; Hysi, PG; Iles, MM; Justice, AE; Kanoni, S; Lagou, V; Li, R; Li, X; Locke, A; Lu, C; Magi, R; Perry, JRB; Pers, TH; Qi, QB; Sanna, M; Schmidt, EM; Scott, WR; Shungin, D; Teumer, A; Vinkhuyzen, AAE; Walker, RW; Westra, HJ; Zhang, MF; Zhang, WH; Zhao, JH; Zhu, ZH; Afzal, U; Ahluwalia, TS; Bakker, SJL; Bellis, C; Bonnefond, A; Borodulin, K; Buchman, AS; Cederholm, T; Choh, AC; Choi, HJ; Curran, JE; de Groot, LCPGM (Lisette); De Jager, PL; Dhonukshe-Rutten, RAM; Enneman, Anke; Eury, E; Evans, DS; Forsen, T; Friedrich, N; Fumeron, F; Garcia, ME; Gartner, S; Han, BG; Havulinna, AS; Hayward, C; Hernandez, D; Hillege, H; Ittermann, T; Kent, JW; Kolcic, I; Laatikainen, T; Lahti, J; Leach, IM; Lee, CG; Lee, JY; Liu, T; Liu, YF; Lobbens, S; Loh, M; Lyytikainen, LP; Medina-Gomez, C; Michaelsson, K; Nalls, MA; Nielson, CM; Oozageer, L; Pascoe, L; Paternoster, L; Polasek, O; Ripatti, S; Sarzynski, MA; Shin, CS; Narancic, NS; Spira, D; Srikanth, P; Steinhagen-Thiessen, E; Sung, YJ; Swart, KMA; Taittonen, L; Tanaka, T; Tikkanen, E; van der Velde, Nathalie; Schoor, NM; Verweij, N (Niek); Wright, AF; Yu, L; Zmuda, JM; Eklund, N; Forrester, T; Grarup, N; Jackson, AU; Kristiansson, K; Kuulasmaa, T; Kuusisto, J; Lichtner, P; Luan, JA; Mahajan, A; Mannisto, S; Palmer, CD; Ried, JS; Scott, RA; Stancakova, A; Wagner, PJ; Demirkan, Ayse; Doring, A; Gudnason, V; Kiel, DP; Kuhnel, B; Mangino, M; McKnight, B; Menni, C; O'Connell, JR; Oostra, Ben; Shuldiner, AR; Song, KJ; Vandenput, L; Duijn, Cornelia; Vollenweider, P; White, CC; Boehnke, M; Boettcher, Y; Cooper, RS; Forouhi, NG; Gieger, C; Grallert, H; Hingorani, A; Jorgensen, T; Jousilahti, P; Kivimaki, M; Kumari, M; Laakso, M; Langenberg, C; Linneberg, A; Luke, A; McKenzie, CA; Palotie, A; Pedersen, O; Peters, A; Strauch, K; Tayo, BO; Wareham, NJ; Bennett, DA; Bertram, L; Blangero, J; Bluher, M; Bouchard, C; Campbell, H; Cho, NH; Cummings, SR; Czerwinski, SA; Demuth, I; Eckardt, R; Eriksson, JG; Ferrucci, L; Franco Duran, OH; Froguel, P; Gansevoort, RT; Hansen, T; Harris, TB; Hastie, N; Heliovaara, M; Hofman, Bert; Jordan, JM; Jula, A; Kahonen, M; Kajantie, E; Knekt, PB; Koskinen, S; Kovacs, P; Lehtimaki, T; Lind, L; Liu, YM; Orwoll, ES; Osmond, C; Perola, M; Perusse, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Rivadeneira, Fernando; Rudan, I; Salomaa, V; Sorensen, TIA; Stumvoll, M; Tonjes, A; Towne, B; Tranah, GJ; Tremblay, A; Uitterlinden, André; van der Harst, P; Vartiainen, E; Viikari, JS; Vitart, V; Vohl, MC; Volzke, H; Walker, M; Wallaschofski, H; Wild, S; Wilson, JF; Yengo, L; Bishop, DT; Borecki, IB; Chambers, JC; Cupples, LA; Dehghan, Abbas; Deloukas, P; Fatemifar, G; Fox, C; Furey, TS; Franke, L; Han, JL; Hunter, DJ; Karjalainen, J; Karpe, F; Kaplan, RC; Kooner, JS; McCarthy, MI; Murabito, JM; Morris, AP; Bishop, JAN; North, KE; Ohlsson, C; Ong, KK; Prokopenko, I; Richards, JB; Schadt, EE; Spector, TD; Widen, E; Willer, CJ; Yang, Jiaqi; Ingelsson, E; Mohlke, KL; Hirschhorn, JN; Pospisilik, JA; Zillikens, M.C.; Lindgren, C; Kilpelainen, TO; Loos, RJF.
In: Nature Communications, Vol. 7, 2016.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
AU - Lu, YC
AU - Day, FR
AU - Gustafsson, S
AU - Buchkovich, ML
AU - Na, JB
AU - Bataille, V
AU - Cousminer, DL
AU - Dastani, Z
AU - Drong, AW
AU - Esko, T
AU - Evans, DM
AU - Falchi, M
AU - Feitosa, MF
AU - Ferreira, T
AU - Hedman, AK
AU - Haring, R
AU - Hysi, PG
AU - Iles, MM
AU - Justice, AE
AU - Kanoni, S
AU - Lagou, V
AU - Li, R
AU - Li, X
AU - Locke, A
AU - Lu, C
AU - Magi, R
AU - Perry, JRB
AU - Pers, TH
AU - Qi, QB
AU - Sanna, M
AU - Schmidt, EM
AU - Scott, WR
AU - Shungin, D
AU - Teumer, A
AU - Vinkhuyzen, AAE
AU - Walker, RW
AU - Westra, HJ
AU - Zhang, MF
AU - Zhang, WH
AU - Zhao, JH
AU - Zhu, ZH
AU - Afzal, U
AU - Ahluwalia, TS
AU - Bakker, SJL
AU - Bellis, C
AU - Bonnefond, A
AU - Borodulin, K
AU - Buchman, AS
AU - Cederholm, T
AU - Choh, AC
AU - Choi, HJ
AU - Curran, JE
AU - de Groot, LCPGM (Lisette)
AU - De Jager, PL
AU - Dhonukshe-Rutten, RAM
AU - Enneman, Anke
AU - Eury, E
AU - Evans, DS
AU - Forsen, T
AU - Friedrich, N
AU - Fumeron, F
AU - Garcia, ME
AU - Gartner, S
AU - Han, BG
AU - Havulinna, AS
AU - Hayward, C
AU - Hernandez, D
AU - Hillege, H
AU - Ittermann, T
AU - Kent, JW
AU - Kolcic, I
AU - Laatikainen, T
AU - Lahti, J
AU - Leach, IM
AU - Lee, CG
AU - Lee, JY
AU - Liu, T
AU - Liu, YF
AU - Lobbens, S
AU - Loh, M
AU - Lyytikainen, LP
AU - Medina-Gomez, C
AU - Michaelsson, K
AU - Nalls, MA
AU - Nielson, CM
AU - Oozageer, L
AU - Pascoe, L
AU - Paternoster, L
AU - Polasek, O
AU - Ripatti, S
AU - Sarzynski, MA
AU - Shin, CS
AU - Narancic, NS
AU - Spira, D
AU - Srikanth, P
AU - Steinhagen-Thiessen, E
AU - Sung, YJ
AU - Swart, KMA
AU - Taittonen, L
AU - Tanaka, T
AU - Tikkanen, E
AU - van der Velde, Nathalie
AU - Schoor, NM
AU - Verweij, N (Niek)
AU - Wright, AF
AU - Yu, L
AU - Zmuda, JM
AU - Eklund, N
AU - Forrester, T
AU - Grarup, N
AU - Jackson, AU
AU - Kristiansson, K
AU - Kuulasmaa, T
AU - Kuusisto, J
AU - Lichtner, P
AU - Luan, JA
AU - Mahajan, A
AU - Mannisto, S
AU - Palmer, CD
AU - Ried, JS
AU - Scott, RA
AU - Stancakova, A
AU - Wagner, PJ
AU - Demirkan, Ayse
AU - Doring, A
AU - Gudnason, V
AU - Kiel, DP
AU - Kuhnel, B
AU - Mangino, M
AU - McKnight, B
AU - Menni, C
AU - O'Connell, JR
AU - Oostra, Ben
AU - Shuldiner, AR
AU - Song, KJ
AU - Vandenput, L
AU - Duijn, Cornelia
AU - Vollenweider, P
AU - White, CC
AU - Boehnke, M
AU - Boettcher, Y
AU - Cooper, RS
AU - Forouhi, NG
AU - Gieger, C
AU - Grallert, H
AU - Hingorani, A
AU - Jorgensen, T
AU - Jousilahti, P
AU - Kivimaki, M
AU - Kumari, M
AU - Laakso, M
AU - Langenberg, C
AU - Linneberg, A
AU - Luke, A
AU - McKenzie, CA
AU - Palotie, A
AU - Pedersen, O
AU - Peters, A
AU - Strauch, K
AU - Tayo, BO
AU - Wareham, NJ
AU - Bennett, DA
AU - Bertram, L
AU - Blangero, J
AU - Bluher, M
AU - Bouchard, C
AU - Campbell, H
AU - Cho, NH
AU - Cummings, SR
AU - Czerwinski, SA
AU - Demuth, I
AU - Eckardt, R
AU - Eriksson, JG
AU - Ferrucci, L
AU - Franco Duran, OH
AU - Froguel, P
AU - Gansevoort, RT
AU - Hansen, T
AU - Harris, TB
AU - Hastie, N
AU - Heliovaara, M
AU - Hofman, Bert
AU - Jordan, JM
AU - Jula, A
AU - Kahonen, M
AU - Kajantie, E
AU - Knekt, PB
AU - Koskinen, S
AU - Kovacs, P
AU - Lehtimaki, T
AU - Lind, L
AU - Liu, YM
AU - Orwoll, ES
AU - Osmond, C
AU - Perola, M
AU - Perusse, L
AU - Raitakari, OT
AU - Rankinen, T
AU - Rao, DC
AU - Rice, TK
AU - Rivadeneira, Fernando
AU - Rudan, I
AU - Salomaa, V
AU - Sorensen, TIA
AU - Stumvoll, M
AU - Tonjes, A
AU - Towne, B
AU - Tranah, GJ
AU - Tremblay, A
AU - Uitterlinden, André
AU - van der Harst, P
AU - Vartiainen, E
AU - Viikari, JS
AU - Vitart, V
AU - Vohl, MC
AU - Volzke, H
AU - Walker, M
AU - Wallaschofski, H
AU - Wild, S
AU - Wilson, JF
AU - Yengo, L
AU - Bishop, DT
AU - Borecki, IB
AU - Chambers, JC
AU - Cupples, LA
AU - Dehghan, Abbas
AU - Deloukas, P
AU - Fatemifar, G
AU - Fox, C
AU - Furey, TS
AU - Franke, L
AU - Han, JL
AU - Hunter, DJ
AU - Karjalainen, J
AU - Karpe, F
AU - Kaplan, RC
AU - Kooner, JS
AU - McCarthy, MI
AU - Murabito, JM
AU - Morris, AP
AU - Bishop, JAN
AU - North, KE
AU - Ohlsson, C
AU - Ong, KK
AU - Prokopenko, I
AU - Richards, JB
AU - Schadt, EE
AU - Spector, TD
AU - Widen, E
AU - Willer, CJ
AU - Yang, Jiaqi
AU - Ingelsson, E
AU - Mohlke, KL
AU - Hirschhorn, JN
AU - Pospisilik, JA
AU - Zillikens, M.C.
AU - Lindgren, C
AU - Kilpelainen, TO
AU - Loos, RJF
PY - 2016
Y1 - 2016
N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
U2 - 10.1038/ncomms10495
DO - 10.1038/ncomms10495
M3 - Article
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
ER -