Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

T de Vos, AD Flaxman, M Naghavi, R Lozano, C Michaud, M Ezzati, K Shibuya, JA Salomon, S Abdalla, V Aboyans, J Abraham, I Ackerman, R Aggarwal, SY Ahn, MK Ali, M Alvarado, HR Anderson, LM Anderson, KG Andrews, C AtkinsonLM Baddour, AN Bahalim, S Barker-Collo, LH Barrero, DH Bartels, MG Basanez, A Baxter, ML Bell, EJ Benjamin, D Bennett, E Bernabe, K Bhalla, B Bhandari, B Bikbov, A Bin Abdulhak, G Birbeck, JA Black, H Blencowe, JD Blore, F Blyth, I Bolliger, A Bonaventure, SA Boufous, R Bourne, M Boussinesq, T Braithwaite, C Brayne, L Bridgett, S Brooker, P Brooks, TS Brugha, C Bryan-Hancock, C Bucello, R Buchbinder, GR Buckle, CM Budke, M Burch, P Burney, R Burstein, B Calabria, B Campbell, CE Canter, H Carabin, J Carapetis, L Carmona, C Cella, F Charlson, HL Chen, ATA Cheng, D Chou, SS Chugh, Luc Coffeng, SD Colan, S Colquhoun, KE Colson, J Condon, MD Connor, LT Cooper, M Corriere, M Cortinovis, KC de Vaccaro, W Couser, BC Cowie, MH Criqui, M Cross, KC Dabhadkar, M Dahiya, N Dahodwala, J Damsere-Derry, G Danaei, A Davis, D De Leo, L Degenhardt, R Dellavalle, A Delossantos, J Denenberg, S Derrett, DC Des Jarlais, SD Dharmaratne, M Dherani, C Diaz-Torne, H Dolk, ER Dorsey, T Driscoll, H Duber, B Ebel, K Edmond, A Elbaz, SE Ali, H Erskine, PJ Erwin, P Espindola, SE Ewoigbokhan, F Farzadfar, V Feigin, DT Felson, A Ferrari, CP Ferri, EM Fevre, MM Finucane, S Flaxman, L Flood, K Foreman, MH Forouzanfar, FGR Fowkes, R Franklin, Mirjam Fransen, MK Freeman, BJ Gabbe, SE Gabriel, E Gakidou, HA Ganatra, B Garcia, F Gaspari, RF Gillum, G Gmel, R Gosselin, R Grainger, J Groeger, F Guillemin, D Gunnell, R Gupta, J Haagsma, H Hagan, YA Halasa, W Hall, D Haring, JM Haro, JE Harrison, R Havmoeller, RJ Hay, H Higashi, C Hill, B Hoen, H Hoffman, PJ Hotez, D Hoy, JJ Huang, SE Ibeanusi, KH Jacobsen, SL James, D Jarvis, R Jasrasaria, S Jayaraman, N Johns, JB Jonas, G Karthikeyan, N Kassebaum, N Kawakami, A Keren, JP Khoo, CH King, LM Knowlton, O Kobusingye, A Koranteng, R Krishnamurthi, R Lalloo, LL Laslett, T Lathlean, JL Leasher, YY Lee, J Leigh, SS Lim, E Limb, JK Lin, M Lipnick, SE Lipshultz, W (Wei) Liu, M Loane, SL Ohno, R Lyons, JX Ma, J Mabweijano, MF MacIntyre, R Malekzadeh, L Mallinger, S Manivannan, W Marcenes, L March, DJ Margolis, GB Marks, R Marks, A Matsumori, R Matzopoulos, BM Mayosi, JH McAnulty, MM McDermott, N McGill, J McGrath, ME Medina-Mora, M Meltzer, GA Mensah, TR Merriman, AC Meyer, V Miglioli, M Miller, TR Miller, PB Mitchell, AO Mocumbi, TE Moffitt, AA Mokdad, L Monasta, M Montico, M Moradi-Lakeh, A Moran, L Morawska, R Mori, ME Murdoch, MK Mwaniki, K Naidoo, MN Nair, L Naldi, KMV Narayan, PK Nelson, RG Nelson, MC Nevitt, CR Newton, S Nolte, P Norman, R Norman, M O'Donnell, Simon O'Hanlon, C Olives, SB Omer, K Ortblad, R Osborne, D Ozgediz, A Page, B Pahari, JD Pandian, AP Rivero, SB Patten, N Pearce, RP Padilla, F Perez-Ruiz, N Perico, K Pesudovs, D Phillips, MR Phillips, K Pierce, S Pion, GV Polanczyk, Suzanne Polinder, CA Pope, S Popova, E Porrini, F Pourmalek, M Prince, RL Pullan, KD Ramaiah, D Ranganathan, H Razavi, M Regan, JT Rehm, DB Rein, G Remuzzi, K Richardson, FP Rivara, T Roberts, C Robinson, FR De Leon, L Ronfani, R Room, LC Rosenfeld, L Rushton, RL Sacco, S Saha, U Sampson, L Sanchez-Riera, E Sanman, DC Schwebel, JG Scott, M Segui-Gomez, S Shahraz, DS Shepard, H Shin, R Shivakoti, D Singh, GM Singh, JA Singh, J Singleton, DA Sleet, K Sliwa, E Smith, JL Smith, NJC Stapelberg, A Steer, T Steiner, Wilma Stolk, LJ Stovner, C Sudfeld, S Syed, G Tamburlini, M Tavakkoli, HR Taylor, JA Taylor, WJ Taylor, B Thomas, WM Thomson, GD Thurston, IM Tleyjeh, M Tonelli, JRA Towbin, T Truelsen, MK Tsilimbaris, C Ubeda, EA Undurraga, MJ (Marieke) van der Werf, J van Os, MS Vavilala, N Venketasubramanian, MR Wang, WZ Wang, K Watt, DJ Weatherall, MA Weinstock, R Weintraub, MG Weisskopf, MM Weissman, RA White, H Whiteford, ST Wiersma, JD Wilkinson, HC Williams, SRM Williams, E Witt, F Wolfe, AD Woolf, S Wulf, PH Yeh, AKM Zaidi, ZJ Zheng, D Zonies, AD Lopez, CJL Murray

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Abstract

Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For m Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0.37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leadi Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but no
Original languageUndefined/Unknown
Pages (from-to)2163-2196
Number of pages34
JournalLancet (UK)
Volume380
Issue number9859
DOIs
Publication statusPublished - 2012

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