TY - JOUR
T1 - Zika virus and the current outbreak
T2 - an overview
AU - Goeijenbier, M
AU - Slobbe, L
AU - van der Eijk, A
AU - de Mendonça Melo, M
AU - Koopmans, M P G
AU - Reusken, C B E M
PY - 2016/3
Y1 - 2016/3
N2 - Zika virus (ZIKV), a mosquito-borne flavivirus closely related to yellow fever virus and dengue virus, is currently causing a large outbreak in the Americas. Historically, ZIKV infection was considered a sporadic, relatively mild disease characterised by fever, maculopapular rash, conjunctivitis and often arthralgia. However, current observational studies suggest that ZIKV may cause more severe neurological sequelae such as Guillain-Barre syndrome, and birth defects, mainly microcephaly, in babies of whom the mother was infected with ZIKV during pregnancy. This article provides a clinically focussed overview of ZIKV, with emphasis on the current outbreak, clinical manifestations, diagnostic tools and caveats.
AB - Zika virus (ZIKV), a mosquito-borne flavivirus closely related to yellow fever virus and dengue virus, is currently causing a large outbreak in the Americas. Historically, ZIKV infection was considered a sporadic, relatively mild disease characterised by fever, maculopapular rash, conjunctivitis and often arthralgia. However, current observational studies suggest that ZIKV may cause more severe neurological sequelae such as Guillain-Barre syndrome, and birth defects, mainly microcephaly, in babies of whom the mother was infected with ZIKV during pregnancy. This article provides a clinically focussed overview of ZIKV, with emphasis on the current outbreak, clinical manifestations, diagnostic tools and caveats.
M3 - Review article
C2 - 27020989
SN - 0300-2977
VL - 74
SP - 104
EP - 109
JO - Netherlands Journal of Medicine
JF - Netherlands Journal of Medicine
IS - 3
ER -
