Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

A. E. Ades; Elizabeth B. Brickley; Neal Alexander; David Brown; Thomas Jaenisch; Demócrito De Barros Miranda-Filho; Moritz Pohl; Kerstin D. Rosenberger; Antoni Soriano-Arandes; Claire Thorne; Ricardo Arraes De Alencar Ximenes; Thalia Velho Barreto De Araújo; Vivian I. Avelino-Silva; Sarah Esperanza Bethencourt Castillo; Victor Hugo Borja Aburto; Patrícia Brasil; Celia D.C. Christie; Wayner Vieira De Souza; Jose Eduardo Gotuzzo H; Bruno Hoen; Marion Koopmans; Celina Maria Turchi Martelli; Mauro Martins Teixeira; Ernesto T.A. Marques; Maria Consuelo Miranda; Ulisses Ramos Montarroyos; Maria Elisabeth Moreira; J. Glenn Morris; Barry Rockx; Paola Mariela Saba Villarroel; Carmen Soria Segarra; Adriana Tami; Marília Dalva Turchi; Carlo Giaquinto; Xavier De Lamballerie; Annelies Wilder-Smith

doi:10.1136/bmjopen-2019-035307

Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

A. E. Ades
, Elizabeth B. Brickley
, Neal Alexander
, David Brown
, Thomas Jaenisch
, Demócrito De Barros Miranda-Filho
, Moritz Pohl
, Kerstin D. Rosenberger
, Antoni Soriano-Arandes
, Claire Thorne^*
, Ricardo Arraes De Alencar Ximenes
, Thalia Velho Barreto De Araújo
, Vivian I. Avelino-Silva
, Sarah Esperanza Bethencourt Castillo
, Victor Hugo Borja Aburto
, Patrícia Brasil
, Celia D.C. Christie
, Wayner Vieira De Souza
, Jose Eduardo Gotuzzo H
, Bruno Hoen

Marion Koopmans, Celina Maria Turchi Martelli, Mauro Martins Teixeira, Ernesto T.A. Marques, Maria Consuelo Miranda, Ulisses Ramos Montarroyos, Maria Elisabeth Moreira, J. Glenn Morris, Barry Rockx, Paola Mariela Saba Villarroel, Carmen Soria Segarra, Adriana Tami, Marília Dalva Turchi, Carlo Giaquinto, Xavier De Lamballerie, Annelies Wilder-Smith

^*Corresponding author for this work

Virology

Bristol Medical School
London School of Hygiene and Tropical Medicine
Mato Grosso Do sul
University Hospital Heidelberg
Universidade Federal de Pernambuco
Heidelberg University
Vall d'Hebron Institute of Oncology
Great Ormond Street Institute of Child Health
Universidade de São Paulo
Universidad de Carabobo
Hospital Pediatría Centro Médico Nacional century XXI
The University of the West Indies
Universidad Peruana Cayetano Heredia
Centre Hospitalier Universitaire de Pointe-à-Pitre
Université des Antilles et de la Guyane
Universidade Federal de Minas Gerais
University of Pittsburgh
Universidade de Pernambuco
University of Florida
Centro Nacional de Enfermedades Tropicales
Universidad Católica de Santiago de Guayaquil
SOSECALI C. Ltda
University Medical Centre Groningen
Universidade Federal de Goiás
University of Padua
Aix-Marseille Université
Umeå University
Universidad Industrial de Santander

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

65 Downloads (Pure)

Abstract

Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

Original language	English
Article number	e035307
Journal	BMJ Open
Volume	10
Issue number	12
DOIs	https://doi.org/10.1136/bmjopen-2019-035307
Publication status	Published - 15 Dec 2020

Bibliographical note

Funding Information:
Funding European Union Directorate-General for Research grant numbers 734 548 (ZIKAlliance), 734 584 (ZikaPLAN) and 734 857 (ZIKAction) Horizon 2020 programme of the European Commission. EBB was also supported by Wellcome Trust & the UK’s Department for International Development (205377/Z/16/Z to LCR; https://wellcome.ac.uk/).

Funding Information:
Competing interests All authors have completed the ICMJE uniform disclosure form. The following authors report grants from the European Commission (AEA, EBB, NA, DB, TJ, KDR, CT, CDCC, AS-A, JGM, CG, Xd-L, AW-S); EBB reports funding from by Wellcome Trust & the UK’s Department for International Development; MT reports grants from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil and from Fundacao de Amparo a Pesquisa do EStado de MInas Gerais (FAPEMIG, Brazil), during the conduct of the study; MK has a patent on zika diagnostics pending.

Publisher Copyright:
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

Ades, A. E., Brickley, E. B., Alexander, N., Brown, D., Jaenisch, T., Miranda-Filho, D. D. B., Pohl, M., Rosenberger, K. D., Soriano-Arandes, A., Thorne, C., Ximenes, R. A. D. A., De Araújo, T. V. B., Avelino-Silva, V. I., Castillo, S. E. B., Aburto, V. H. B., Brasil, P., Christie, C. D. C., De Souza, W. V., Gotuzzo H, J. E., ... Wilder-Smith, A. (2020). Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. BMJ Open, 10(12), Article e035307. https://doi.org/10.1136/bmjopen-2019-035307

@article{2bbdb5378d524f5687720e2b30d0e996,

title = "Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia",

abstract = "Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities. ",

author = "Ades, \{A. E.\} and Brickley, \{Elizabeth B.\} and Neal Alexander and David Brown and Thomas Jaenisch and Miranda-Filho, \{Dem{\'o}crito De Barros\} and Moritz Pohl and Rosenberger, \{Kerstin D.\} and Antoni Soriano-Arandes and Claire Thorne and Ximenes, \{Ricardo Arraes De Alencar\} and \{De Ara{\'u}jo\}, \{Thalia Velho Barreto\} and Avelino-Silva, \{Vivian I.\} and Castillo, \{Sarah Esperanza Bethencourt\} and Aburto, \{Victor Hugo Borja\} and Patr{\'i}cia Brasil and Christie, \{Celia D.C.\} and \{De Souza\}, \{Wayner Vieira\} and \{Gotuzzo H\}, \{Jose Eduardo\} and Bruno Hoen and Marion Koopmans and Martelli, \{Celina Maria Turchi\} and \{Martins Teixeira\}, Mauro and Marques, \{Ernesto T.A.\} and Miranda, \{Maria Consuelo\} and Montarroyos, \{Ulisses Ramos\} and Moreira, \{Maria Elisabeth\} and Morris, \{J. Glenn\} and Barry Rockx and Villarroel, \{Paola Mariela Saba\} and \{Soria Segarra\}, Carmen and Adriana Tami and Turchi, \{Mar{\'i}lia Dalva\} and Carlo Giaquinto and \{De Lamballerie\}, Xavier and Annelies Wilder-Smith",

note = "Funding Information: Funding European Union Directorate-General for Research grant numbers 734 548 (ZIKAlliance), 734 584 (ZikaPLAN) and 734 857 (ZIKAction) Horizon 2020 programme of the European Commission. EBB was also supported by Wellcome Trust \& the UK{\textquoteright}s Department for International Development (205377/Z/16/Z to LCR; https://wellcome.ac.uk/). Funding Information: Competing interests All authors have completed the ICMJE uniform disclosure form. The following authors report grants from the European Commission (AEA, EBB, NA, DB, TJ, KDR, CT, CDCC, AS-A, JGM, CG, Xd-L, AW-S); EBB reports funding from by Wellcome Trust \& the UK{\textquoteright}s Department for International Development; MT reports grants from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil and from Fundacao de Amparo a Pesquisa do EStado de MInas Gerais (FAPEMIG, Brazil), during the conduct of the study; MK has a patent on zika diagnostics pending. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.",

year = "2020",

month = dec,

day = "15",

doi = "10.1136/bmjopen-2019-035307",

language = "English",

volume = "10",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "12",

}

Ades, AE, Brickley, EB, Alexander, N, Brown, D, Jaenisch, T, Miranda-Filho, DDB, Pohl, M, Rosenberger, KD, Soriano-Arandes, A, Thorne, C, Ximenes, RADA, De Araújo, TVB, Avelino-Silva, VI, Castillo, SEB, Aburto, VHB, Brasil, P, Christie, CDC, De Souza, WV, Gotuzzo H, JE, Hoen, B, Koopmans, M, Martelli, CMT, Martins Teixeira, M, Marques, ETA, Miranda, MC, Montarroyos, UR, Moreira, ME, Morris, JG, Rockx, B, Villarroel, PMS, Soria Segarra, C, Tami, A, Turchi, MD, Giaquinto, C, De Lamballerie, X & Wilder-Smith, A 2020, 'Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia', BMJ Open, vol. 10, no. 12, e035307. https://doi.org/10.1136/bmjopen-2019-035307

TY - JOUR

T1 - Zika virus infection in pregnancy

T2 - A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

AU - Ades, A. E.

AU - Brickley, Elizabeth B.

AU - Alexander, Neal

AU - Brown, David

AU - Jaenisch, Thomas

AU - Miranda-Filho, Demócrito De Barros

AU - Pohl, Moritz

AU - Rosenberger, Kerstin D.

AU - Soriano-Arandes, Antoni

AU - Thorne, Claire

AU - Ximenes, Ricardo Arraes De Alencar

AU - De Araújo, Thalia Velho Barreto

AU - Avelino-Silva, Vivian I.

AU - Castillo, Sarah Esperanza Bethencourt

AU - Aburto, Victor Hugo Borja

AU - Brasil, Patrícia

AU - Christie, Celia D.C.

AU - De Souza, Wayner Vieira

AU - Gotuzzo H, Jose Eduardo

AU - Hoen, Bruno

AU - Koopmans, Marion

AU - Martelli, Celina Maria Turchi

AU - Martins Teixeira, Mauro

AU - Marques, Ernesto T.A.

AU - Miranda, Maria Consuelo

AU - Montarroyos, Ulisses Ramos

AU - Moreira, Maria Elisabeth

AU - Morris, J. Glenn

AU - Rockx, Barry

AU - Villarroel, Paola Mariela Saba

AU - Soria Segarra, Carmen

AU - Tami, Adriana

AU - Turchi, Marília Dalva

AU - Giaquinto, Carlo

AU - De Lamballerie, Xavier

AU - Wilder-Smith, Annelies

N1 - Funding Information: Funding European Union Directorate-General for Research grant numbers 734 548 (ZIKAlliance), 734 584 (ZikaPLAN) and 734 857 (ZIKAction) Horizon 2020 programme of the European Commission. EBB was also supported by Wellcome Trust & the UK’s Department for International Development (205377/Z/16/Z to LCR; https://wellcome.ac.uk/). Funding Information: Competing interests All authors have completed the ICMJE uniform disclosure form. The following authors report grants from the European Commission (AEA, EBB, NA, DB, TJ, KDR, CT, CDCC, AS-A, JGM, CG, Xd-L, AW-S); EBB reports funding from by Wellcome Trust & the UK’s Department for International Development; MT reports grants from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil and from Fundacao de Amparo a Pesquisa do EStado de MInas Gerais (FAPEMIG, Brazil), during the conduct of the study; MK has a patent on zika diagnostics pending. Publisher Copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

AB - Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

UR - https://www.scopus.com/pages/publications/85098534238

U2 - 10.1136/bmjopen-2019-035307

DO - 10.1136/bmjopen-2019-035307

M3 - Article

C2 - 33323426

AN - SCOPUS:85098534238

SN - 2044-6055

VL - 10

JO - BMJ Open

JF - BMJ Open

IS - 12

M1 - e035307

ER -

Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

Abstract

Bibliographical note

UN SDGs

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