International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

Pieter-Jan van Dam; Eric P van der Stok; Laure-Anne Teuwen; Gert G Van den Eynden; Martin Illemann; Sophia Frentzas; Ali W Majeed; Rikke L Eefsen; Robert R J Coebergh van den Braak; Anthoula Lazaris; Maria Celia Fernandez; Boris Galjart; Ole Didrik Laerum; Roni Rayes; Dirk J Grünhagen; Michelle Van de Paer; Yves Sucaet; Hardeep Singh Mudhar; Michael Schvimer; Hanna Nyström; Mark Kockx; Nigel C Bird; Fernando Vidal-Vanaclocha; Peter Metrakos; Eve Simoneau; Cornelis Verhoef; Luc Y Dirix; Steven Van Laere; Zu-Hua Gao; Pnina Brodt; Andrew R Reynolds; Peter B Vermeulen

doi:10.1038/bjc.2017.334

International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

Pieter-Jan van Dam
, Eric P van der Stok
, Laure-Anne Teuwen
, Gert G Van den Eynden
, Martin Illemann
, Sophia Frentzas
, Ali W Majeed
, Rikke L Eefsen
, Robert R J Coebergh van den Braak
, Anthoula Lazaris
, Maria Celia Fernandez
, Boris Galjart
, Ole Didrik Laerum
, Roni Rayes
, Dirk J Grünhagen
, Michelle Van de Paer
, Yves Sucaet
, Hardeep Singh Mudhar
, Michael Schvimer
, Hanna Nyström

Mark Kockx, Nigel C Bird, Fernando Vidal-Vanaclocha, Peter Metrakos, Eve Simoneau, Cornelis Verhoef, Luc Y Dirix, Steven Van Laere, Zu-Hua Gao, Pnina Brodt, Andrew R Reynolds^*, Peter B Vermeulen^*

^*Corresponding author for this work

Surgery

GZA - Sint Augustinus Hospital
Copenhagen University Hospital (Herlev)
Institute of Cancer Research (ICR), London
Sheffield Teaching Hospitals NHS Foundation Trust
Naestved Hospital
Research Institute of the McGill University Health Centre
Department of Pathology
Royal Hallamshire Hospital
New South Wales Health Pathology - Institute of Clinical Pathology and Medical Research
Umeå University
HistoGeneX NV
University of Sheffield
Catholic University of Valencia
McGill University

Research output: Contribution to journal › Article › Academic › peer-review

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47 Downloads (Pure)

Abstract

BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.

METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.

RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).

CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

Original language	English
Pages (from-to)	1427-1441
Number of pages	15
Journal	British Journal of Cancer
Volume	117
Issue number	10
DOIs	https://doi.org/10.1038/bjc.2017.334
Publication status	Published - 7 Nov 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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van Dam, P.-J., van der Stok, E. P., Teuwen, L.-A., Van den Eynden, G. G., Illemann, M., Frentzas, S., Majeed, A. W., Eefsen, R. L., Coebergh van den Braak, R. R. J., Lazaris, A., Fernandez, M. C., Galjart, B., Laerum, O. D., Rayes, R., Grünhagen, D. J., Van de Paer, M., Sucaet, Y., Mudhar, H. S., Schvimer, M., ... Vermeulen, P. B. (2017). International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. British Journal of Cancer, 117(10), 1427-1441. https://doi.org/10.1038/bjc.2017.334

@article{f39b55d517574e458cd52144f8f33953,

title = "International consensus guidelines for scoring the histopathological growth patterns of liver metastasis",

abstract = "BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H\&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.",

author = "\{van Dam\}, Pieter-Jan and \{van der Stok\}, \{Eric P\} and Laure-Anne Teuwen and \{Van den Eynden\}, \{Gert G\} and Martin Illemann and Sophia Frentzas and Majeed, \{Ali W\} and Eefsen, \{Rikke L\} and \{Coebergh van den Braak\}, \{Robert R J\} and Anthoula Lazaris and Fernandez, \{Maria Celia\} and Boris Galjart and Laerum, \{Ole Didrik\} and Roni Rayes and Gr{\"u}nhagen, \{Dirk J\} and \{Van de Paer\}, Michelle and Yves Sucaet and Mudhar, \{Hardeep Singh\} and Michael Schvimer and Hanna Nystr{\"o}m and Mark Kockx and Bird, \{Nigel C\} and Fernando Vidal-Vanaclocha and Peter Metrakos and Eve Simoneau and Cornelis Verhoef and Dirix, \{Luc Y\} and \{Van Laere\}, Steven and Zu-Hua Gao and Pnina Brodt and Reynolds, \{Andrew R\} and Vermeulen, \{Peter B\}",

year = "2017",

month = nov,

day = "7",

doi = "10.1038/bjc.2017.334",

language = "English",

volume = "117",

pages = "1427--1441",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "10",

}

van Dam, P-J, van der Stok, EP, Teuwen, L-A, Van den Eynden, GG, Illemann, M, Frentzas, S, Majeed, AW, Eefsen, RL, Coebergh van den Braak, RRJ, Lazaris, A, Fernandez, MC, Galjart, B, Laerum, OD, Rayes, R, Grünhagen, DJ, Van de Paer, M, Sucaet, Y, Mudhar, HS, Schvimer, M, Nyström, H, Kockx, M, Bird, NC, Vidal-Vanaclocha, F, Metrakos, P, Simoneau, E, Verhoef, C, Dirix, LY, Van Laere, S, Gao, Z-H, Brodt, P, Reynolds, AR & Vermeulen, PB 2017, 'International consensus guidelines for scoring the histopathological growth patterns of liver metastasis', British Journal of Cancer, vol. 117, no. 10, pp. 1427-1441. https://doi.org/10.1038/bjc.2017.334

TY - JOUR

T1 - International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

AU - van Dam, Pieter-Jan

AU - van der Stok, Eric P

AU - Teuwen, Laure-Anne

AU - Van den Eynden, Gert G

AU - Illemann, Martin

AU - Frentzas, Sophia

AU - Majeed, Ali W

AU - Eefsen, Rikke L

AU - Coebergh van den Braak, Robert R J

AU - Lazaris, Anthoula

AU - Fernandez, Maria Celia

AU - Galjart, Boris

AU - Laerum, Ole Didrik

AU - Rayes, Roni

AU - Grünhagen, Dirk J

AU - Van de Paer, Michelle

AU - Sucaet, Yves

AU - Mudhar, Hardeep Singh

AU - Schvimer, Michael

AU - Nyström, Hanna

AU - Kockx, Mark

AU - Bird, Nigel C

AU - Vidal-Vanaclocha, Fernando

AU - Metrakos, Peter

AU - Simoneau, Eve

AU - Verhoef, Cornelis

AU - Dirix, Luc Y

AU - Van Laere, Steven

AU - Gao, Zu-Hua

AU - Brodt, Pnina

AU - Reynolds, Andrew R

AU - Vermeulen, Peter B

PY - 2017/11/7

Y1 - 2017/11/7

N2 - BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

AB - BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

U2 - 10.1038/bjc.2017.334

DO - 10.1038/bjc.2017.334

M3 - Article

C2 - 28982110

SN - 0007-0920

VL - 117

SP - 1427

EP - 1441

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

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